General Clinical Research Ctr Suppl-Immunology Core Lab

描述（由申请人提供）： 本提案是对Meharry-Vanderbilt联盟GCRC人类免疫学核心实验室的补充申请。 该提案的目标是在各种领域的临床研究背景下促进对人类免疫反应的详细研究，包括免疫学，流变学，传染病，疫苗学，肺部医学和癌症治疗。拟议的实验室服务将允许NIH资助的临床研究人员将当前的临床研究方案扩展到免疫系统在疾病中的作用的机制研究或正在研究的治疗方法。 该提案的直接目的是支持一个稳定，灵活，集中的基础设施，用于复杂的免疫学检测，这将使研究能够促进和协调人类免疫学的多学科基础和临床研究。该计划的长期目标是促进使用动物模型的研究从以前的炎症或免疫感染研究转化为人类的临床应用。 迄今为止，这些概念的转化受到所需测定的复杂性、设备和试剂的成本以及运行测定所需的高水平专业培训的阻碍。 这些因素阻碍了许多有才华的临床研究人员在他们的研究中研究人类免疫元件的作用。 拟议的核心将促进临床研究人员获得可重复的检测方法，并将为临床研究团队提供科学咨询，以选择适当的检测方法和解释数据。 新的和年轻的研究者优先获得核心服务将鼓励这些研究者将免疫学研究纳入新的和原始的临床研究。

DESCRIPTION (provided by applicant): This proposal is a supplemental request for a GCRC Human Immunology Core Laboratory for the Meharry-Vanderbilt Alliance. The goal of the proposal is to foster detailed studies of the human immune response in the context of clinical investigation in a diverse array of fields, including immunology, rheumatology, infectious diseases, vaccinology, pulmonary medicine and cancer therapy. The laboratory services proposed will allow NIH-funded clinical investigators to extend current protocols of clinical investigation into mechanistic studies of the role of the immune system in the disease or therapeutic approaches under study. The immediate purpose of the proposal is to support a stable, flexible, centralized infrastructure for sophisticated immunology assays that will enable research needed to promote and coordinate multidisciplinary basic and clinical research in human immunology. A long-term goal of this program is to promote the translation of research using animal models from previous studies of inflammation or immunity to infection into clinical applications in humans. To date, translation of these concepts has been hindered by the complexity of the assays needed, the cost of equipment and reagents, and the high level of specialized training required to run the assays. Such factors have barred many talented clinical investigators from investigating the role of human immune elements in their studies. The proposed Core will facilitate the availability of reproducible assays to clinical researchers, and will provide for scientific consultation to the clinical research teams for the selection of appropriate tests and interpretation of data. Priority access to the Core services for new and young investigators will encourage these investigators to incorporate immunologic studies into new and original clinical studies.