GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 8356650
• 负责人: CHRISTINA C. WANG
• 金额: --
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356650
• 关键词: Alcohol dependence; Atherosclerosis; Autoimmunity; Behavior; Chronic Kidney Failure; Clinical Research; Clinical Sciences; Complex; Cytology; Data; Diabetes Mellitus; Diabetic Nephropathy; Discipline; Disease; Environment; Equipment; Faculty; Fibroblasts; Funding; Genetic; Genomics; Genotype; Grant; Health; Human Resources; Infection; Inflammatory Bowel Diseases; Inpatients; Institution; Joints; Kidney Diseases; Medical center; Mental Depression; Methamphetamine; Minority; Molecular; Monitor; National Center for Research Resources; Osteoporosis; Outpatients; Pediatrics; Perinatal; Phenotype; Positioning Attribute; Principal Investigator; Proteomics; Protocols documentation; Reproduction; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Running; Safety; Sampling Studies; Source; Students; Toxicology; Training; Training Activity; Translational Research; United States National Institutes of Health; Visit; Work; base; cost; male; metabolic abnormality assessment; nutrition; parent grant; phase 1 study; reproductive; skeletal dysplasia

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The GCRC at Harbor-UCLA Medical Center and the satellite GCRC at Cedars-Sinai Medical Center are applying for continued funding of the GCRCs for 5 years (12/01/2006 to 11/30/2011). The Harbor-UCLA GCRC is requesting support for an inpatient unit (800 days), outpatient facilities (9,000 visits), a perinatal/ pediatrics unit (7,000 hrs). The Cedars GCRC satellite is seeking continued support for an outpatient unit, a complex genotype-phenotype core and a perinatal unit working closely with its Harbor counterpart. The current application contains 93 protocols from Harbor and 95 from Cedars, each with Data Safety Monitoring plans. The GCRCs are requesting support for a new joint Clinjcal Transcriptional Genomics, Proteomics and Molecular Cytology core with 47 protocols utilizing this proposed core. Reviewed and given an excellent score, this core was not funded in 2004 because of NCRR's budgetary constraints. Similar to the GCRC parent grant, the core's strengths include outstanding qualifications of the investigators-core directors, the capability to provide a training environment, and a substantial number of investigators and protocols from a broad range of disciplines. Our institutions have generously provided major equipment in the past 2 years and provided interim support for personnel to run the proposed core. Our presented proto-cols demonstrate the broad base of our well-funded investigators with diverse research including emerging infections, chronic kidney disease, fibroblasts in autoimmunity, male reproduction, neurotrauma, skeletal dysplasia and inflammatory bowel disease. We support high-volume outpatient studies (SELECT, Nutrition and Kidney Disease), high-intensity inpatient studies (Phase I safety and pharmacokihetics studies, metabolic and multiple sample studies), perinatal research (reproductive toxicology, methamphetamine exposed babies), behavior studies (depression, alcohol dependence), and genetics of common diseases (diabetes, diabetic nephropathy, osteoporosis, atherosclerosis). The GCRCs are the focus of clinical research training in their respective institutions reaching out to junior faculty, fellows, and minority graduate and undergraduate students, and our training activity is ranked "outstanding" in our last review. The GCRCs are positioned to be part of Centers for Clinical and Translational Sciences in our institutions following the NIH Roadmap to reengineer the clinical research enterprise of academic health centers in the nation.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 Harbour-UCLA医疗中心和Cedars-Sinai医疗中心的卫星GCRC的GCRC是 申请GCRC的持续资金5年（2006年12月1日至11/30/2011）。港口 - 乌克拉群岛 GCRC要求支持住院单位（800天），门诊设施（9,000次访问），围产期/ 儿科单元（7,000小时）。雪松GCRC卫星正在寻求持续支持门诊单位 复杂的基因型 - 表型核心和围产期单元与港口对应物紧密合作。这 当前申请包含来自Harbor的93个协议，Cedars包含95个协议，每个协议均包含数据安全监控 计划。 GCRC要求支持新的联合临床转录基因组学，蛋白质组学 和分子细胞学核心，具有47个方案，利用该提议的核心。审查并给予了极好的 得分，由于NCRR的预算限制，该核心在2004年没有资助。类似于GCRC 父母赠款，核心的优势包括调查员核心董事的出色资格， 提供培训环境的能力，以及大量的调查人员和协议 广泛的学科。在过去的两年中，我们的机构慷慨地提供了主要设备 并为人员提供了临时支持，以运行拟议的核心。我们提出的原型演示 我们资金丰富的研究人员的广泛研究基础，包括新兴感染，慢性感染 肾脏疾病，自身免疫性中的成纤维细胞，男性繁殖，神经疾病，骨骼发育不良和 炎症性肠病。我们支持高体积门诊研究（选择，营养和肾脏 疾病），高强度的住院研究（I期安全和药物学研究，代谢和 多个样本研究），围产期研究（生殖毒理学，甲基苯丙胺暴露的婴儿）， 行为研究（抑郁，酒精依赖）和常见疾病的遗传学（糖尿病，糖尿病患者 肾病，骨质疏松症，动脉粥样硬化）。 GCRC是其临床研究培训的重点 各自的机构接触初级教师，研究员和少数群体毕业生和本科生 学生，我们的培训活动在我们的上一篇评论中排名为“出色”。 GCRC定位为 在NIH路线图之后，我们机构中的临床和转化科学中心的一部分是重新设计师 美国学术卫生中心的临床研究企业。