GENERAL CLINICAL RESEARCH CENTER

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 港湾-加州大学洛杉矶分校医疗中心的GCRC和锡达斯-西奈医疗中心的卫星GCRC是 申请继续资助综合资源中心5年(2006年12月1日至2011年11月30日)。港湾-加州大学洛杉矶分校 GCRC请求为住院病房(800天)、门诊设施(9000次就诊)、围产期/ 儿科(7,000小时)。Cedars GCRC卫星正在为一家门诊部寻求持续支持 复杂的基因型-表型核心和一个与其港湾同行密切合作的围产期单位。这个 当前的应用程序包含来自Harbor的93个协议和来自Cedars的95个协议，每个协议都带有数据安全监控 计划。GCRC正在请求支持一项新的联合临床转录基因组学，蛋白质组学 和分子细胞学核心，使用该提议的核心的47个协议。审阅并给予优秀的 由于NCRR的预算限制，2004年没有为这一核心项目提供资金。类似于GCRC Parent Grant，核心的优势包括调查人员的杰出资质-核心董事， 提供培训环境的能力，以及来自 学科的范围很广。在过去的两年里，我们的机构慷慨地提供了主要设备 并为运行拟议核心的人员提供临时支助。我们提出的协议演示了 我们资金雄厚的调查人员拥有广泛的基础，他们进行了包括新发感染、慢性感染在内的各种研究 肾脏疾病，自身免疫中的成纤维细胞，男性生殖，神经创伤，骨骼发育不良和 炎症性肠病。我们支持大量的门诊研究(选择、营养和肾脏 疾病)、高强度住院研究(第一阶段安全性和药效学研究、代谢和 多样本研究)、围产期研究(生殖毒理学、接触甲基苯丙胺的婴儿)、 行为研究(抑郁症、酒精依赖)和常见疾病的遗传学(糖尿病、糖尿病 肾病、骨质疏松症、动脉粥样硬化)。GCRC是临床研究培训的重点 各自的机构接触初级教员、研究员和少数族裔毕业生和本科生 我们的培训活动在上一次的评估中被评为“杰出”。GCR的定位是 我们机构的部分临床和翻译科学中心遵循NIH路线图进行重新设计 全国学术卫生中心临床研究企业。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The GCRC at Harbor-UCLA Medical Center and the satellite GCRC at Cedars-Sinai Medical Center are applying for continued funding of the GCRCs for 5 years (12/01/2006 to 11/30/2011). The Harbor-UCLA GCRC is requesting support for an inpatient unit (800 days), outpatient facilities (9,000 visits), a perinatal/ pediatrics unit (7,000 hrs). The Cedars GCRC satellite is seeking continued support for an outpatient unit, a complex genotype-phenotype core and a perinatal unit working closely with its Harbor counterpart. The current application contains 93 protocols from Harbor and 95 from Cedars, each with Data Safety Monitoring plans. The GCRCs are requesting support for a new joint Clinjcal Transcriptional Genomics, Proteomics and Molecular Cytology core with 47 protocols utilizing this proposed core. Reviewed and given an excellent score, this core was not funded in 2004 because of NCRR's budgetary constraints. Similar to the GCRC parent grant, the core's strengths include outstanding qualifications of the investigators-core directors, the capability to provide a training environment, and a substantial number of investigators and protocols from a broad range of disciplines. Our institutions have generously provided major equipment in the past 2 years and provided interim support for personnel to run the proposed core. Our presented proto-cols demonstrate the broad base of our well-funded investigators with diverse research including emerging infections, chronic kidney disease, fibroblasts in autoimmunity, male reproduction, neurotrauma, skeletal dysplasia and inflammatory bowel disease. We support high-volume outpatient studies (SELECT, Nutrition and Kidney Disease), high-intensity inpatient studies (Phase I safety and pharmacokihetics studies, metabolic and multiple sample studies), perinatal research (reproductive toxicology, methamphetamine exposed babies), behavior studies (depression, alcohol dependence), and genetics of common diseases (diabetes, diabetic nephropathy, osteoporosis, atherosclerosis). The GCRCs are the focus of clinical research training in their respective institutions reaching out to junior faculty, fellows, and minority graduate and undergraduate students, and our training activity is ranked "outstanding" in our last review. The GCRCs are positioned to be part of Centers for Clinical and Translational Sciences in our institutions following the NIH Roadmap to reengineer the clinical research enterprise of academic health centers in the nation.