STRUCTURE DETERMINATION OF RACEMIC D L MONELLIN IN CENTROSYMMETRIC SPACE GROUP

外消旋DL莫内林中心对称空间群的结构测定

• 批准号: 6586527
• 负责人: SUNG-HOU KIM
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586527
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; proteins; radiography; structural biology

The protein monellin is one of the most potently sweet compounds known. We produced the racemic DL monellin by mixing equal amounts of Native (L) monellin and All-D monellin. The intensity statistics of data 6-3.5 E showed high possibility of a centrosymmetric structure. However, 2.0 E refinement without centrommetric constrains suggests that there may be a non-centric relationship between D and L molecules and/or water structure around the molecules. To resolve this issue, which has significant implication to scientists interested in origin of chirality in biosphere and in origin of life, we need to obtain data with highest possible resolution.

莫内林蛋白是最强甜味的化合物之一 知道的 我们通过混合等量的 天然（L）莫内林和全D莫内林。 的强度统计 数据6- 3.5E显示中心对称结构的高可能性。 然而，没有质心约束的2.0 E细化表明 D和L分子之间可能存在非中心关系 和/或分子周围的水结构。 为了解决这个问题， 这对那些对起源感兴趣的科学家来说意义重大 在生物圈和生命起源中的手性，我们需要获得 尽可能高的分辨率。