STRUCTURE DETERMINATION OF PROTEINS INVOLVED IN SIGNAL TRANSDUCTION

参与信号转导的蛋白质的结构测定

• 批准号: 6586554
• 负责人: SUNG-HOU KIM
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586554
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; proteins; radiography; structural biology

Rapid progress in the functional characterization of proteins involved in signal transduction and cell cycle regulation has highlighted their importance for appropriate signal responses and regulation of cell differentiation, cell growth and cell division. We are working on the crystal structure of a complex of cyclin dependent kinase 2 with cyclin A. CDKs are central to cell cycle regulation and can only be activated after complex formation with a cyclin. Hence a complex structure will provide important structural information about the activation process of CDK2.

蛋白质功能表征的快速进展 参与信号转导和细胞周期调节 强调了它们对于适当信号响应的重要性以及 细胞分化、细胞生长和细胞分裂的调节。 我们 正在研究细胞周期蛋白依赖性复合物的晶体结构 激酶 2 与细胞周期蛋白 A。CDK 是细胞周期调节的核心， 仅在与细胞周期蛋白形成复合物后才能被激活。 因此一个 复杂的结构将提供重要的结构信息 CDK2的激活过程。