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STRUCTURE OF COMPLEX BETWEEN TFIIIA & ITS 31 BP DNA SITE

STRUCTURE OF COMPLEX BETWEEN TFIIIA & ITS 31 BP DNA SITE
TFIIIA 之间的复合体结构
批准号:
6586625
负责人:
STEPHEN COPLAN HARRISON
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28

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中文摘要
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英文摘要
Multiple zinc finger motifs were originally discovered in Xenopus transcription factor IIIA (TFIIIA). Each motif is an independently folded protein domain. Nine tandem zinc fingers are present in TFIIIA, allowing the protein to bind to an extensive region of the 5S RNA gene promoter. There is a relatively "standard" docking of most of the fingers represented in set into the major groove of DNA, but the GLI structure shows one finger with essentially no DNA contacts. Thus, proteins with more than 3 fingers may have highly divergent docking modes. The goal of the present study is to examine a still longer complex.
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Structural biology of antibody:antigen complexes
  • 批准号:
    8516984
  • 项目类别:
  • 资助金额:
    $37.29万
  • 财政年份:
    2013
  • 负责人:
    STEPHEN COPLAN HARRISON
  • 依托单位:
Administrative Core
  • 批准号:
    8516985
  • 项目类别:
  • 资助金额:
    $4.99万
  • 财政年份:
    2013
  • 负责人:
    STEPHEN COPLAN HARRISON
  • 依托单位:
Structural biology of antibody:antigen complexes
  • 批准号:
    8377204
  • 项目类别:
  • 资助金额:
    $25.45万
  • 财政年份:
    2012
  • 负责人:
    STEPHEN COPLAN HARRISON
  • 依托单位:
Administrative Core
  • 批准号:
    8377206
  • 项目类别:
  • 资助金额:
    $12.87万
  • 财政年份:
    2012
  • 负责人:
    STEPHEN COPLAN HARRISON
  • 依托单位:
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