DETERMINATION OF STRUCTURE OF HIGH AFFINITY IGE RECEPTOR FROM MAST CELLS
DETERMINATION OF STRUCTURE OF HIGH AFFINITY IGE RECEPTOR FROM MAST CELLS
批准号:
6586528
负责人:
Theodore S Jardetzky
金额:
$14.32万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-03-01 至 2003-02-28
中文摘要
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英文摘要
We have produced crystals of the extracellular domain of the high
affinity IgE receptor from mast cells. This receptor provides a
crucial link between soluble antibody and cell-based mechanisms of
immunity. The receptor-IgE interaction is the key molecular
recognition step associated with immediate-type hypersensitivities
such as allergic and anaphylactic shock reactions. The crystals
diffract weakly on laboratory sources and we are requesting time to
collect high resolution data at SSRL.
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会议论文
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Development of an IgE:Receptor Fluorescence Assay For High Throughput Screening
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依托单位:
海外基金