STRUCTURE DETERMINATION OF PEPTIDYLGLYCINE HYDROXYLATING MONOOXGENASE

PHM的结构研究将在几个方面产生重大影响 研究领域。他们将提供一个结构模型进行测试 建议的反应机制，提供药理学信息 帮助合成生物活性激素，提供第一个 一种新的酶类的结构，可能还有一种新的折叠基序， 为研究DBM的结构和反应机理提供了模型 通过同源性，并提供了对观察到的 底物专一性。

Structural studies of PHM will have a great impact in several areas of research. They will provide a structural model to test proposed reaction mechanisms, provide pharmacological information aiding the synthesis of bioactive hormones, provide the first structure of a novel enzyme class and perhaps a novel folding motif, provide a model to study the structure and reaction mechanism of DbM through homology and provide a structural explanation of the observed substrate specificity.