NEURONAL AND CHEMICAL CONTROL OF BREATHING AN AIRWAYS FU
呼吸气道 FU 的神经元和化学控制
基本信息
- 批准号:6661846
- 负责人:
- 金额:$ 10.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-30 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
An adequate gas exchange and a sufficient supply of 02 to tissues depends on the patency of the airways which are regulated by central and peripheral nervous systems. The Howard University response to this RFA is based on the need for fundamental research in regard to central and peripheral nervous control of breathing and airway functions; including olfaction. Disturbances in neuronal regulatory mechanisms, as a consequences of alterations in sensory and/or motor innervations at different levels of organization, may cause serious health problems. To address some of these issues, we propose four interrelated projects. Project 1 will define central determinants of breathing and airway instability during behavioral changes by examining how CNS sites that regulate rapid eye movements (REM) and quiet (non-REM sleep might exert a differential control on respiratory related skeletal and airway smooth muscles. project 2 will study the neurochemical profile of the central chemoreceptor neurons, their receptor types, as well as their neuronal projections to respiratory and airway related motoneurons. Project 3 will investigate gene regulation involved in plasticity of the olfactory system as well as signaling during the acute phase response to physical, chemical and biological stressors. Project 4 will investigate the role of sensory innervation of the airway and gene regulatory mechanisms triggered by environmental agents, which operate in a feed forward manner enhancing airway inflammation and bronchoconstriction, and alterations in the signaling system linked to airway hyper-reactivity, airway narrowing and refractoriness to airway dilating influences. New investigative approaches will be used in these studies to answer questions which will enhance our understanding of the fundamental mechanisms underlying regulation of respiratory and airway functions. Furthermore, assembling a team of multi-disciplinary scientists from outside of the Howard University research community will enable us to generate new information that will advance knowledge, and ask relevant questions regarding future studies. This proposal is an expression of the commitments made by the College of Medicine, investing in infrastructure and guaranteeing long-term support, to bring talented researchers to work together. The university is committed to provide appropriate release time for the participants in this program to perform the research described herein.
充分的气体交换和向组织提供足够的O 2 取决于由中枢和周围神经系统调节的气道的通畅性。霍华德大学对此 RFA 的回应是基于对呼吸和气道功能的中枢和外周神经控制的基础研究的需要;包括嗅觉。由于组织不同层次的感觉和/或运动神经支配改变,神经元调节机制的紊乱可能会导致严重的健康问题。为了解决其中一些问题,我们提出了四个相互关联的项目。项目 1 将通过检查调节快速眼动 (REM) 和安静(非快速眼动睡眠)的中枢神经系统位点如何对呼吸相关的骨骼和气道平滑肌发挥差异性控制来定义行为变化期间呼吸和气道不稳定的中心决定因素。项目 2 将研究中枢化学感受器神经元的神经化学特征、它们的受体类型以及它们对呼吸和气道相关的神经元投射 运动神经元。项目 3 将研究涉及嗅觉系统可塑性的基因调控以及对物理、化学和生物应激源的急性期反应期间的信号传导。项目4将研究环境因素触发的气道感觉神经支配和基因调节机制的作用,这些机制以前馈方式增强气道炎症和支气管收缩,以及与气道相关的信号系统的改变 过度反应、气道狭窄和对气道扩张影响的抵抗力。这些研究将采用新的研究方法来回答问题,从而增强我们对呼吸和气道功能调节基本机制的理解。此外,组建来自霍华德大学研究界之外的多学科科学家团队将使我们能够产生新的信息,从而推进知识的发展,并提出有关未来研究的相关问题。这个 该提案体现了医学院的承诺,即投资基础设施并保证长期支持,以吸引才华横溢的研究人员共同工作。大学致力于为该计划的参与者提供适当的释放时间来进行本文所述的研究。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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MUSA A HAXHIU其他文献
MUSA A HAXHIU的其他文献
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{{ truncateString('MUSA A HAXHIU', 18)}}的其他基金
Neural Control of Breathing and Cardiovascular Function
呼吸和心血管功能的神经控制
- 批准号:
6613286 - 财政年份:2003
- 资助金额:
$ 10.31万 - 项目类别:
Neural Control of Breathing and Cardiovascular Function
呼吸和心血管功能的神经控制
- 批准号:
6948868 - 财政年份:2003
- 资助金额:
$ 10.31万 - 项目类别:
Neural Control of Breathing and Cardiovascular Function
呼吸和心血管功能的神经控制
- 批准号:
6801509 - 财政年份:2003
- 资助金额:
$ 10.31万 - 项目类别:
Central determinants of airway instability during sleep
睡眠期间气道不稳定的主要决定因素
- 批准号:
6664649 - 财政年份:2002
- 资助金额:
$ 10.31万 - 项目类别:
Central determinants of airway instability during sleep
睡眠期间气道不稳定的主要决定因素
- 批准号:
6662897 - 财政年份:2002
- 资助金额:
$ 10.31万 - 项目类别:
Central determinants of airway instability during sleep
睡眠期间气道不稳定的主要决定因素
- 批准号:
6504186 - 财政年份:2001
- 资助金额:
$ 10.31万 - 项目类别:
Central determinants of airway instability during sleep
睡眠期间气道不稳定的主要决定因素
- 批准号:
6357121 - 财政年份:2000
- 资助金额:
$ 10.31万 - 项目类别:
NEURONAL AND CHEMICAL CONTROL OF BREATHING AN AIRWAYS FU
呼吸气道 FU 的神经元和化学控制
- 批准号:
6529603 - 财政年份:1999
- 资助金额:
$ 10.31万 - 项目类别:
NEURONAL AND CHEMICAL CONTROL OF BREATHING AN AIRWAYS FU
呼吸气道 FU 的神经元和化学控制
- 批准号:
6953527 - 财政年份:1999
- 资助金额:
$ 10.31万 - 项目类别: