AMYGDALA AND CENTRAL CONTROL OF THE AIRWAYS

杏仁核和气道的中央控制

• 批准号: 6992630
• 负责人: MUSA A HAXHIU
• 金额: $ 8.18万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6992630
• 关键词: allergens; amygdala; asthma; behavioral /social science research tag; cats; emotions; fear; inflammation; minority institution research support; neuroanatomy; neurobiology; neurons; neuropsychology; neuroregulation; panic disorder; pathologic process; preganglionic fiber; respiratory system

Bronchial asthma, a disease characterized by airway hyperresponsiveness and airway narrowing, is a potentially lethal, frequently disabling, and almost invariably associated with substantive emotional distress. Anxiety and the panic-fear symptom constellation has been shown to occur at higher rates in people with asthma compared to non-asthmatic subjects. In turn, disturbances in emotional state contribute to worsening of bronchial asthma and may act as risk factors for poor outcome. Neural pathways through which bronchial asthma generate fear and anger, causing autonomic changes that in turn exacerbate asthma at a psychophysiological level, are not known. Hence, the Iongterm objective of this proposal is to understand neural network and mechanisms that link emotional control with regulation airway homeostasis. Studies will focus on regulation of the airway geometry by the amygdaloid complex, which is thought to be involved in anxiety and the panic-fear syndrome. In the proposed studies, we will characterize operational network that link central amygdala with the vagal preganglionic neurons that innervate the tracheobronchial system, as a common pathway integrating the critical changes that set the stage for emotional distress and airway hyperresponsiveness. These studies will be performed in cats over a three-year period. The results of these studies will greatly enhance our understanding of the interrelationship between limbic system and central control of the airways and will have important implications for elucidating the pathophysiology of anxiety and the panic-fear expression with asthmatic attacks and designing therapeutic strategies to reduce or alleviate emotional and respiratory consequences of airway narrowing.

支气管哮喘是一种以气道高反应性和气道狭窄为特征的疾病，是一种潜在的致命性疾病，经常致残，几乎总是与实质性的情绪困扰有关。与非哮喘受试者相比，哮喘患者的焦虑和恐慌恐惧症状发生率更高。反过来，情绪状态的紊乱会导致支气管哮喘的恶化，并可能成为预后不良的危险因素。支气管哮喘通过神经通路产生恐惧和愤怒，引起自主神经变化，进而在心理生理水平上加剧哮喘，目前尚不清楚。因此，本研究的长期目标是了解情绪控制与调节气道内稳态之间的神经网络和机制。研究将集中在杏仁核复合体对气道几何形状的调节上，杏仁核复合体被认为与焦虑和恐慌恐惧综合征有关。在拟议的研究中，我们将描述连接中央杏仁核和支配气管支气管系统的迷走神经节前神经元的操作网络，作为整合情绪困扰和气道的关键变化的共同途径。 高反应性这些研究将在猫中进行，为期三年。这些研究的结果将大大提高我们的边缘系统和中央控制的气道之间的相互关系的理解，并将有重要的意义，阐明焦虑的病理生理学和恐慌恐惧的表达与哮喘发作和设计治疗策略，以减少或减轻情绪和呼吸的气道狭窄的后果。