MOLECULAR BIOLOGY

描述：分子生物学项目由14名教员组成，他们 跨越学术级别，包括一些新加入MSKCC的人。这群人 有来自R01和其他资助机制的强有力的同行审查赠款支持。 重点领域是涉及DNA合成的基因表达和 与生物体有关的转录机制和调控机制 发育和细胞分化。了解这些过程是 是我们关于生长控制和致癌知识的基础。 复制和转录组的成员仍然大致相同 稳定。发育生物学小组的新成员位于 距离彼此很近，离果蝇繁育设施很近。其中三个 新成员得到了核心赠款的支持。七个成员中的许多人 发育生物学小组每周在期刊俱乐部召开会议并分享 协作项目。预计将再增加一到两名工作人员 受雇于发育生物学领域。每周有一次进行中的工作 本计划的午餐会，参加会议的成员来自内部或来自其他国家 节目或机构发言。细胞生物学和分子生物学 项目有一个合并的每周研究生研究研讨会。有一个 年度计划务虚会。博士之间协作互动的陈述。 玛丽安博士、马萨格博士和舒曼博士之间的拓扑异构酶 赫维茨关于DNA复制和其他一些次要的相互作用。

Description: The Molecular Biology Program consists of fourteen faculty who span the academic ranks, including a number who are new to MSKCC. The group has strong peer reviewed grant support from R01s and other funding mechanisms. The areas of emphasis are gene expression involving DNA synthesis and transcriptional mechanisms, and regulatory mechanisms involved in organismal development and cell differentiation. Understanding these processes is fundamental to our knowledge of growth control and carcinogenesis. The membership of the Replication and Transcription Group remain gnerally stable. The new members of the Developmental Biology Group are located in proximity to each other and to the Drosophila breeding facility. Three of the new members have been supported by the core grant. Many of the seven member Developmental Biology Group meet weekly in a journal club setting and share collaborative projects. It is envisioned that one or two more staff will be hired in the developmental biology area. There is a weekly Work-in-Progress luncheon meeting of the program at which members from within or from other programs or institutions speak. The Cell Biology and Molecular Biology Programs have a combined weekly graduate student research seminar. There is a yearly program retreat. Statements of collaborative interactions between Drs. Marians and Shuman on topoisomerases, between Drs. Marian, Massague and Hurwitz on DNA replication and some other minor interactions are presented.