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Integrated PhD Training Program in Cancer Biology

癌症生物学综合博士培训计划

基本信息

批准号：
7293596
负责人：
KENNETH J MARIANS
金额：
$ 21.81万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7293596
关键词：
17-(Allylamino)-17-demethoxygeldanamycin Acceleration Achievement Address Admission activity Advisory Committees Agreement Air Annual Reports Antibodies Antibody Therapy Antigen Presentation Pathway Antineoplastic Agents Apoptosis Appendix Appointment Area Arts Assimilations Association of American Medical Colleges Attention Award Back Basic Science Benchmarking Binding Biochemical Biochemistry Bioinformatics Biological Biological Models Biological Sciences Biology Biometry Blood Body of uterus Books Bypass Camptothecin Cancer Biology Cancer Center Cancer Etiology Cancer Immunology Science Cancer Model Cell Adhesion Cell Cycle Cell Cycle Regulation Cell-Matrix Junction Cells Cellular Membrane Cellular biology Chemicals Chemistry Chromosomal translocation Chromosome Segregation Chromosome Structures Chromosomes Chromosomes, Human, Pair 4 Chromosomes, Human, Pair 5 Cities Class Clinic Clinical Clinical Data Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Clinical effectiveness Clonality Colon Carcinoma Combined Modality Therapy Commit Committee Members Communication Communities Complex Computational Biology Computers Condition Consensus Consultations Critiques Cytogenetics DNA Damage DNA Gyrase DNA Sequence Rearrangement DNA-Protein Interaction Daily Data Dependence Depth Development Developmental Biology Diagnosis Disabled Persons Discrimination Disease Disease Management Doctor of Medicine Doctor of Philosophy Dose Double Strand Break Repair Drug Formulations Drug Kinetics Drug resistance Education Educational Curriculum Educational process of instructing Effectiveness Endocytosis Pathway Endoplasmic Reticulum Enrollment Ensure Environment Enzymes Epidemiology Epigenetic Process Equilibrium Equipment Erinaceidae Etoposide Evaluation Event Evidence Based Medicine Evolution Exposure to Faculty Familiarity Feedback Floor Fostering Foundations Funding Geldanamycin Gene Expression Generations Genes Genetic Genetic Counseling Genetic Recombination Genetic Transcription Genitourinary system Genome Genomics Germ cell tumor Goals Graduate Education Grant Growth Guidelines HSP 90 inhibition Head Heat-Shock Proteins 90 Heat-Shock Response Histones Histopathology Hodgkin Disease Holidays Home environment Hormones Hospitals Hour Human Human Resources Image Imagery Immersion Investigative Technique Immune system Immunity Immunologic Surveillance Immunology Immunotherapy Individual Infection Institution Instruction Internet Intervention Interview Journals Knowledge Laboratories Laboratory Finding Laboratory Research Lead Leadership Learning Lesion Letters Life Link Literature Location Logic Lymphoma Malignant Neoplasms Malignant neoplasm of prostate Malignant neoplasm of testis Measurement Mechanics Medical Medical Education Medicine Meiosis Meiotic Recombination Membrane Structure and Function Memorial Sloan-Kettering Cancer Center Mentors Metabolic Pathway Metabolism Methods Mission Mitogen-Activated Protein Kinases Mitotic Mitotic Checkpoint Modeling Modification Molecular Molecular Biology Molecular Chaperones Molecular Conformation Molecular Profiling Molecular Target Monitor Morphogenesis Mutate Mutation Natural History Natural Immunity Nature Neoplasm Metastasis New York New York City Non-Malignant Nonhomologous DNA End Joining Nucleosides Nucleotides Numbers Oncogene Proteins Oncogenic Oral Oral Examination Organ Organelles Organic Chemistry Organogenesis Ovarian Paclitaxel Paper Pathogenesis Pathology Pathway interactions Patient Care Patients Peptides Performance Personality Persons Pharmaceutical Preparations Pharmacodynamics Pharmacologic Substance Pharmacology Phenotype Phosphotransferases Physicians Physiology Poison Policies Positioning Attribute Postdoctoral Fellow Predisposition Preparation Principal Investigator Process Program Evaluation Progress Reports Proteins Proteome Proteomics Proto-Oncogene Proteins c-akt Published Comment Publishing Quinolones RNA Race Radiation Radiation therapy Range Reading Recommendation Regulation Religion and Sex Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Proposals Research Training Resistance Resolution Resort Resources Reunion Island Role Rotation Route SKI gene Sampling Schedule Schools Science Scientific Misconduct Scientist Second Primary Cancers Self Assessment Series Services Sexual Harassment Side Signal Pathway Signal Transduction Signal Transduction Pathway Signaling Protein Sirolimus Site Solid Neoplasm Source Spectral Karyotyping Stem cells Stress Structure Students Suggestion Supervision Syndrome System TP53 gene Tea Techniques Technology Testing Text Therapeutic Therapeutic Agents Thinking Time Tissues Topoisomerase Toxic effect Training Training Programs Training and Education Translational Research Translations Type I DNA Topoisomerases United States National Institutes of Health Universities Upper arm Ursidae Family Vaccine Therapy Virus Vision Visual Week Work Workload Writing analog angiogenesis antibody conjugate base biological research cancer cell cancer immunology function cancer therapy cancer type career case history cell killing cell motility cell type chaperone machinery chemotherapeutic agent chemotherapy chromatin remodeling chromosome replication cohort college concept cyclobutanecarbonylcarnitine day design drug development drug discovery expectation experience falls forging gene transfer vector genetic linkage analysis grasp handicapping condition homologous recombination human TOP1 protein human disease immunoregulation improved inhibitor/antagonist innovation insight instructor interest knowledge base large cell Diffuse non-Hodgkin&apos s lymphoma lecturer lectures leukemia leukemia/lymphoma malignant breast neoplasm medical schools melanoma member mimetics monorden mouse model multicatalytic endopeptidase complex neoplastic next generation notch protein oncology patient oriented research positional cloning prevent professor programs protein folding protein structure protein structure function remediation repaired research study resistance mechanism response rituximab skills small molecule social structural biology success symposium syntax tool transcription factor translational medicine trend tumor tumorigenesis university student uptake

项目摘要

DESCRIPTION (From the application): The goal of the new Cancer Biology Graduate Program at the Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, is to increase the pace of translation of laboratory findings to clinical practice by introducing a new curriculum in cancer biology aimed at providing Ph.D. researchers with both the basic science training they need to be successful bench scientists and with a strong clinical perspective that includes:, connecting the biology of cancer to its clinical presentation, the challenges of clinical treatment, the workings of patient-oriented research, the process of development of Pharmaceuticals, and an understanding of how human physiology influences mode of intervention. The program accomplishes this with a unique integrated didactic curriculum designed by a team of basic and physician scientists that includes: (i) the Cancer Biology Core Course, which transits from a primarily basic science orientation to a more physiology-based orientation, culminating in "disease modules" that reach back to the basic science sections to explore in depth the underpinnings of the natural history, biology, current treatments, and existing model systems; (ii) bench science thesis research; and (iii) a thesis project-related apprenticeship with a Clinical Mentor, who serves as the student's guide to hospital-based academic activities. The faculty of the Gerstner Sloan-Kettering Graduate School are drawn from both the basic science and clinical arms of the Cancer Center.

描述（来自申请）：纪念斯隆-凯特琳癌症中心小路易斯·格斯特纳生物医学研究生院新的癌症生物学研究生项目的目标是通过引入旨在提供博士学位的新癌症生物学课程，加快将实验室研究结果转化为临床实践的步伐。研究人员既受过成为成功的基础科学家所需的基础科学培训，又具有强大的临床视角，包括：将癌症生物学与其临床表现联系起来、临床治疗的挑战、以患者为导向的研究工作、药物开发过程以及对人类生理学如何影响干预模式的理解。该计划通过由基础科学家和医学科学家团队设计的独特的综合教学课程来实现这一目标，其中包括：（i）癌症生物学核心课程，从主要的基础科学方向转变为更多基于生理学的方向，最终形成“疾病模块”，回到基础科学部分，深入探索自然历史、生物学、当前治疗和现有模型系统的基础； (ii) 基础科学论文研究； (iii) 与临床导师一起进行与论文项目相关的学徒期，临床导师将担任学生在医院开展学术活动的指南。格斯特纳·斯隆-凯特琳研究生院的教职人员来自癌症中心的基础科学和临床部门。