Conference on DNA Replication and Recombination

DNA复制与重组会议

• 批准号: 6434547
• 负责人: KENNETH J MARIANS
• 金额: $ 0.7万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6434547
• 关键词: DNA replication; genetic recombination; meeting /conference /symposium

DESCRIPTION (Provided by applicant): The mechanisms of replication and recombination are of fundamental importance to all organisms. Recent research has revealed a crucial connection between these two processes that is essential for the preservation of genome stability in all species. New structural studies promise stunning new insight to the basic mechanisms of the replication fork. And the myriad layers of control of the initiation of eukaryotic replication are being peeled away for inspection. The solution of several current problems is pivotal to future progress. These problems include: identification of the eukaryotic replication fork DNA helicase, establishing the mechanism of initiation of DNA replication at a eukaryotic origin, definition of the mechanisms by which the RecQ-like DNA helicases contribute to genome stability, elucidation of the biochemical pathway of double-strand break formation that initiates meiotic recombination, elaboration of the biochemical pathways of double-strand break repair, and illumination of the crosstalk between the recombination and replication machinery that contributes to replication fork reactivation. The symposium will highlight the most recent findings in these related areas of research and will help keep workers in these growing and fast moving fields abreast of the current state of knowledge. This meeting provides a special opportunity for people working in replication and recombination to benefit from a comprehensive, multi disciplinary view, spanning biological concepts to atomic detail. The fact that the meeting is "open" ensures maximum exposure and accessibility for speakers and participants. The opportunity to present one's work and the "cross-pollination" that this meeting provides can have an important impact on the formulation and direction of the career of graduate students and postdoctorals. This meeting is held only once every three years. It is not duplicated by other meetings in that it is the only one that brings together large numbers of replication and recombination projects. Given the rapid pace of progress in these fields over the last three years, it should prove to be a timely and exciting meeting.

描述（由申请人提供）： 复制和重组的机制至关重要 对所有的生物体。 最近的研究表明， 这两个过程对于保持基因组的稳定性至关重要 在所有物种中。 新的结构研究承诺惊人的新见解， 复制分叉的基本机制。 以及无数的控制层 真核生物复制的起始被剥离以供检查。 解决当前的几个问题对今后的进展至关重要。 这些 问题包括：真核生物复制叉DNA的鉴定 解旋酶，建立了DNA复制起始的机制， 真核生物起源，RecQ样DNA 解旋酶有助于基因组的稳定性，阐明了生物化学 启动减数分裂重组的双链断裂形成途径， 阐述双链断裂修复的生化途径，以及 重组和复制之间的串扰的照明 有助于复制叉重新激活的机制。 座谈会 将重点介绍这些相关研究领域的最新发现， 将有助于使这些不断增长和快速发展的领域的工人与时俱进， 目前的知识状态。 这次会议为以下方面提供了一个特殊的机会： 从事复制和重组工作的人， 全面的，多学科的观点，从生物学概念到原子 详细 会议是“公开的”，这一事实确保了最大限度的曝光， 为演讲者和与会者提供无障碍环境。 展示自己的机会 工作和这次会议提供的“交叉授粉”可以有一个 对研究生职业生涯的形成和走向产生重要影响 学生和博士后。 这一会议每三年举行一次。 它不被其他会议重复，因为它是唯一一个带来 大量的复制和重组项目。 鉴于 在过去三年中，这些领域的进展速度很快， 这是一次及时而令人兴奋的会议。