ROLE FOR MATERNAL HOMOCYST(E)INE IN FETAL METABOLISM?

母体同型半胱氨酸（E）在胎儿代谢中的作用？

• 批准号: 6592349
• 负责人: M R MALINOW
• 金额: $ 11.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6592349
• 关键词: Chordata; growth /development; immunology; inflammation

Data on fetal blood homocyst(e)ine concentrations are not available. We tested the hypothesis that homocyst(e)ine crosses the maternal/placental/fetal interphases and is sequestered by the fetus. The concentration of homocyst(e)ine was determined at parturition in peripheral venous plasma from 35 nulliparous healthy pregnant women and umbilical arterial and venous plasma from their conceptus. Findings demonstrated a descending concentration gradient of plasma homocyst(e)ine from maternal vein to umbilical vein and to umbilical artery; the decrease at each interphase approximated 1 umol/L. The neonate weight and gestational age were inversely related to maternal homocyst(e)ine concentrations. The umbilical vein to umbilical artery homocyst(e)ine decrement suggests that uptake of homocyst(e)ine occurs in the fetus. The likely incorporation of homocyst(e)ine into the fetal metabolic cycle may implicate maternal homocyst(e)ine as having a potential nutritional role in the fetus. Further studies are required to explain the role of homocyst(e)ine in fetal metabolism and development. FUNDING GCRC RR080 PUBLICATIONS Malinow MR, Rajkovic A, Duell PB, Hess DL, Upson BS. The relationship between maternal and neonatal umbilical cord plasma homocyst(e)ine suggests a potential role for maternal homocyst(e)ine in fetal metabolism. Am J Obstet Gynecol 178:228-233, 1998.

胎儿血液同型半胱氨酸浓度的数据尚不清楚 available. 我们测试了同型半胱氨酸穿过 母体/胎盘/胎儿间期并被胎儿隔离。 在分娩时测定了10例孕妇和10例正常孕妇的血清同型半胱氨酸浓度。 35例初产健康孕妇外周静脉血浆 以及胎儿脐动脉和静脉血浆。 结果显示血浆浓度梯度下降 从母体静脉到脐静脉和脐静脉的同型半胱氨酸 动脉;在每个间期下降约1 μ mol/L。 的 新生儿体重和胎龄与母亲体重和胎龄呈负相关， 同型半胱氨酸浓度。 脐静脉至脐动脉 同型半胱氨酸减少表明发生了同型半胱氨酸摄取 在胎儿中。 同型半胱氨酸的可能掺入， 胎儿代谢周期可能暗示母体同囊（e）ine具有 对胎儿有潜在的营养作用 进一步的研究 需要解释同型半胱氨酸在胎儿代谢中的作用， 发展 资助GCRC RR 080出版物Malinow MR，Rajkovic A， Duell PB，Hess DL，Upson BS. 母亲和母亲之间的关系 新生儿脐带血浆同型半胱氨酸提示 母体同型半胱氨酸在胎儿代谢中的作用。 Am J Obstet 妇科178：228-233，1998年。