HOMOCYST(E)INE RESPONSE TO CEREAL FORTIF W/ FOLIC ACID

同型半胱氨酸（E）对含叶酸的谷物强化剂的反应

• 批准号: 6592348
• 负责人: M R MALINOW
• 金额: $ 11.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6592348
• 关键词: Chordata; growth /development; nutrition; nutrition related tag

Numerous observational studies have shown that an elevated level of total plasma (tHCY) is an independent risk factor for arterial occlusive disease, and is associated with venous thrombosis and pulmonary embolism. Moreover, we have reported that experimental elevation of tHCY in nonhuman primates shows acetycholine-induced arterial relaxation, indicating that elevated tHCY alters vascular function. In the majority of cases, elevated tHCY levels are lowered by treatment with supplemental folic acid. On January 1, 1998, due to such folic acid as known to reduce the risk for neural tube defects (NTD) in the developing fetus, the FDA recommended the fortification of certain foods with folic acid by ~100 ?g/day. Further, to test this hypothesis that nationwide fortification of food with folic acid might reduce tHCY, Malinow et al. conducted a clinical trial using breakfast cereal fortified with different levels of folic acid. Results indicated that such cereals containing folic acid (499 ?g and 655 ?g per 30 g of cereal) lowered similarly tHCY in subjects with coronary heart disease, suggesting that ~400 ?g of folic acid provides maximum effect to lower tHCY. The above study will determine whether folic acid fortification (40 ?g/day) has similar effects as supplementation (2.5 mg/day). In a metanalysis, it has been shown that folic acid supplementation between 0.5 and 5.0 mg/day have similar effects on tHCY levels. FUNDING Homocyst(e)ine testing funds PUBLICATIONS None

大量的观测研究表明，水平升高 血浆总含量(THCY)是动脉粥样硬化的独立危险因素 闭塞性疾病，并与静脉血栓形成和 肺栓塞。此外，我们已经报道了试验性的 非人灵长类动物tHCY升高显示乙酰胆碱诱导 动脉松弛，表明tHCY升高改变血管 功能。在大多数情况下，升高的tHCY水平会降低 通过补充叶酸治疗。1998年1月1日，由于 这种已知的叶酸可以降低神经管缺陷的风险 (NTD)在发育中的胎儿中，FDA建议添加 某些食物中含有叶酸的摄入量每天增加约100克。此外，为了测试 这一假设认为，在全国范围内强化食品中的叶酸 可能会降低tHCY，Malinow等人。进行了一项临床试验，使用 早餐麦片中添加了不同水平的叶酸。 结果表明，这种含有叶酸的谷物(499克和 每30克谷类食品中655克)同样降低了tHCY 冠心病，表明~400克的叶酸可以提供 最大限度地降低tHCY的效果。上述研究将确定是否 强化叶酸(40克/天)的效果与 补充剂(2.5毫克/天)。在荟萃分析中，它已经被证明 每天补充0.5到5.0毫克的叶酸 对tHCY水平也有类似的影响。资助同种异型(E)因测试基金 出版物无