REDUCT OF PLASMA HOMOCYST(E)INE LEVELS BY BREAKFAST CEREAL FORTIF W/ FOLIC ACID

通过含叶酸的早餐谷物强化剂降低血浆同型半胱氨酸 (E) 水平

• 批准号: 6592293
• 负责人: M R MALINOW
• 金额: $ 11.11万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6592293
• 关键词: Chordata; immunology; inflammation; nutrition; nutrition related tag

The Food and Drug Administration (FDA) has recommended that cereal-grain products be fortified with folic acid to prevent congenital neural-tube defects. Since folic acid supplementation reduces plasma homocyst(e)ine, or plasma total homocysteine, which is frequently elevated in arterial occlusive disease, we hypothesized that folic acid fortification might reduce plasma homocyst(e)ine levels. To test this hypothesis, we assessed the effects of breakfast cereals fortified with three levels of folic acid, and also containing the recommended dietary allowances of vitamins B6 and B12, in a randomized, double-blinded, placebo-controlled, cross-over trial in 75 men and women with coronary artery disease. Plasma folic acid increased and plasma homocyst(e)ine decreased proportionately with the folic acid content of the breakfast cereal. Cereal providing 127 ?g of folic acid daily, approximating the increased daily intake that may result from the FDA=s enrichment policy, increased plasma folic acid by 30.8% (P=0.045) but decreased plasma homocyst(e)ine by only 3.7% (P= 0.24). However, cereals providing 499 and 665 ?g folic acid daily increased plasma folic acid by 64.8% (P< 0.001) and 105.7% (P= 0.001), respectively, and decreased plasma homocyst(e)ine by 11% (P< 0.001) and 14.0% (P= 0.001), respectively. Cereal fortified with folic acid has the potential to increase plasma folic acid levels and reduce plasma homocyst(e)ine levels. Further clinical trials are required to determine whether folic acid fortification may prevent vascular disease. Until then, our results suggest that folic acid fortification at levels higher than that recommended by the FDA may be warranted. FUNDING General Mills PUBLICATIONS Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC, Upson BM. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med 338:1009-1015, 1998.

美国食品和药物管理局 (FDA) 建议 谷物产品中添加叶酸以预防 先天性神经管缺陷。 自从补充叶酸 降低血浆同型半胱氨酸（e）或血浆总同型半胱氨酸，这是 在动脉闭塞性疾病中经常升高，我们假设 叶酸强化可能会降低血浆高半胱氨酸 水平。 为了检验这个假设，我们评估了早餐的影响 谷物强化了三种水平的叶酸，并且还含有 维生素 B6 和 B12 的推荐膳食摄入量 对 75 名患者进行的随机、双盲、安慰剂对照、交叉试验 患有冠状动脉疾病的男性和女性。 血浆叶酸 血浆同型半胱氨酸增加，血浆同型半胱氨酸减少，与 早餐麦片的叶酸含量。 谷物提供 127 克 每天的叶酸，大约是每日增加的摄入量 FDA = 浓缩政策的结果，血浆叶酸增加 降低 30.8% (P=0.045)，但血浆同型半胱氨酸仅降低 3.7% （P=0.24）。 然而，谷物每天提供 499 和 665 微克叶酸 血浆叶酸增加 64.8% (P< 0.001) 和 105.7% (P= 0.001)， 血浆同型半胱氨酸分别降低 11% (P< 0.001) 分别为 14.0% 和 14.0%（P=0.001）。 叶酸强化谷物 有可能增加血浆叶酸水平并减少 血浆同型半胱氨酸水平。 还需要进一步的临床试验 确定叶酸强化是否可以预防血管疾病 疾病。 在那之前，我们的结果表明叶酸 强化水平可能高于 FDA 推荐的水平 保证。 资助 General Mills 出版物 Malinow MR, Duell PB, 赫斯 DL、安德森 PH、克鲁格 WD、菲利普森 BE、格鲁克曼 RA、Block PC、 厄普森 BM。 早餐可降低血浆同型半胱氨酸水平 冠心病患者服用叶酸强化谷物 疾病。 新英格兰医学杂志 338：1009-1015，1998。