课题基金 / 基金详情

HOMOCYST (E) INE, DIET, & CARDIOVASCULAR DISEASES AMER HEART ASSOC SCI ADVISORY

HOMOCYST (E) INE, DIET, & CARDIOVASCULAR DISEASES AMER HEART ASSOC SCI ADVISORY
同型半胱氨酸 (E) 碱、饮食、
批准号：
6312906
负责人：
M R MALINOW
金额：
$10.1万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-05-01 至 2004-04-30
来源：
https://reporter.nih.gov/project-details/6312906
关键词：
Mammalia animal tissue clinical research endocrine gland /system hormones mental disorders mother /infant health care nervous system reproductive system women's health

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An experiment is underway to determine if the selective estrogen receptor modulators, called raloxifen and SERM 3, alter gene expression in serotonin neurons in the same manner as natural estrogen. Monkeys are spayed and then treated for one month with vehicle, estrogen, raloxifen, or SERM3 at 5 mg/kg/day orally. After treatment, the monkeys are euthanized and the midbrain is obtained for determination of expression of the serotonin reuptake transporter gene and the 5HT1A autoreceptor gene. FUNDING Eli Lilly Pharmaceutical Co. PUBLICATIONS None
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