Homocysteine And Cysteine Interactions

同型半胱氨酸和半胱氨酸相互作用

• 批准号: 6546548
• 负责人: GLEN HORTIN
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6546548
• 关键词: albumins; aminoacid metabolism; atherosclerosis; blood proteins; clinical research; cysteine; disease /disorder proneness /risk; homocysteine; human tissue; protein protein interaction; protein structure function; thrombosis

Increased concentrations of the amino acid homocysteine in blood are recognized as a risk factor for thrombosis and atherosclerosis. Cysteine is a product formed from homocysteine, and increased concentrations of this amino acid may also serve as a risk factor for thrombosis and atherosclerosis. The mechanism of how these amino acids cause or serve as markers for these disorders is not known. Most of these amino acids are bound to albumin or other plasma proteins and mechanisms of exchange of these amino acids are not fully understood. Our studies are examining the distribution of homocysteine and cysteine among plasma proteins and mechanisms of exchange between free and protein-bound forms of these amino acids. Goals of these studies are: 1) To identify which measurements of plasma homocysteine, cysteine, or combinations of amino acid measurements serve as the best risk indicator, 2) To better understand the metabolic relationships of homocysteine and cysteine, 3) To determine whether these amino acids have direct effects on function of plasma proteins.

血液中氨基酸同型半胱氨酸浓度升高被认为是血栓形成和动脉粥样硬化的危险因素。半胱氨酸是由同型半胱氨酸形成的产物，这种氨基酸浓度的增加也可能是血栓和动脉粥样硬化的危险因素。这些氨基酸如何引起这些疾病或作为这些疾病的标志物的机制尚不清楚。这些氨基酸大多与白蛋白或其他血浆蛋白结合，这些氨基酸的交换机制尚不完全清楚。我们的研究正在检查血浆蛋白中同型半胱氨酸和半胱氨酸的分布，以及这些氨基酸的游离形式和蛋白质结合形式之间的交换机制。这些研究的目的是：1)确定血浆同型半胱氨酸、半胱氨酸或氨基酸测量组合的哪些测量值可以作为最佳的风险指标；2)更好地了解同型半胱氨酸和半胱氨酸的代谢关系；3)确定这些氨基酸是否对血浆蛋白的功能有直接影响。