Homocysteine And Cysteine Interactions

同型半胱氨酸和半胱氨酸相互作用

• 批准号: 6675238
• 负责人: GLEN HORTIN
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6675238
• 关键词: albumins; aminoacid metabolism; atherosclerosis; blood proteins; clinical research; cysteine; disease /disorder proneness /risk; homocysteine; human tissue; protein protein interaction; protein structure function; thrombosis

Increased concentrations of the amino acid homocysteine in blood are recognized as a risk factor for thrombosis and atherosclerosis. Cysteine is a product formed from homocysteine, and increased concentrations of this amino acid may also serve as a risk factor for thrombosis and atherosclerosis. The mechanism of how these amino acids cause or serve as markers for these disorders is not known. Most of these amino acids are bound to albumin or other plasma proteins and mechanisms of exchange of these amino acids are not fully understood. Our studies are examining the distribution of homocysteine and cysteine among plasma proteins and mechanisms of exchange between free and protein-bound forms of these amino acids. Goals of these studies are: 1) To identify which measurements of plasma homocysteine, cysteine, or combinations of amino acid measurements serve as the best risk indicator, 2) To better understand the metabolic relationships of homocysteine and cysteine, 3) To determine whether these amino acids have direct effects on function of plasma proteins. A starting point for examining interactions with proteins is to study the binding and exchange of cysteine and homocysteine with different plasma proteins.

血液中氨基酸同型半胱氨酸浓度的增加被认为是血栓形成和动脉粥样硬化的危险因素。半胱氨酸是由同型半胱氨酸形成的产物，这种氨基酸的浓度增加也可能是血栓形成和动脉粥样硬化的危险因素。这些氨基酸如何引起或作为这些疾病的标志物的机制尚不清楚。这些氨基酸中的大多数与白蛋白或其他血浆蛋白结合，这些氨基酸的交换机制尚未完全了解。我们的研究正在检查血浆蛋白中同型半胱氨酸和半胱氨酸的分布以及这些氨基酸的游离形式和蛋白结合形式之间的交换机制。这些研究的目标是：1）确定血浆同型半胱氨酸、半胱氨酸或氨基酸测量组合的哪些测量值作为最佳风险指标，2）更好地了解同型半胱氨酸和半胱氨酸的代谢关系，3）确定这些氨基酸是否对血浆蛋白质的功能有直接影响。研究与蛋白质相互作用的起点是研究半胱氨酸和高半胱氨酸与不同血浆蛋白的结合和交换。