Ultra-fast Mri For Cardiovascular Applications

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ULTRA-FAST MRI FOR CARDIOVASCULAR APPLICATIONS Over the past year we have further developed the ability of MRI systems to image interventional procedures in real-time. We have implemented real-time PR with the ability to toggle off/on a volumetric projection, and real-time FISP imaging sequences tuned to guide interventions in peri-infart zones of the myocardium based on late enhancement after Gd-DTPA injections. We have incorporated new custom reconstruction software with the vendor supplied scan plane control software to view multiple scan planes simultaneously. Real-time control of numerous scanning parameters such as imaging resolution, number of projections, saturation pulses, coil gains, and field shims have been incorporated into the system. Two monitors are available in the scan room for the physician, and two keyboard controls are available at the end of the scanning table. A custom xray/MR patient table has been incorporated into the laboratory. We have now begun a series of animal experiments demonstrating real-time guidance of injection catheters in the left ventricle. We have demonstrated the visualization of needle deployment and injection of contrast agent directly into the myocardium These results will have direct impact on the delivery of therapeutic agents directly into tissues.