BIOMOLECULAR STRUCTURE AND INTERACTIONS

这项研究的目的是确定关键生物分子相互作用的原理。为此，我们将使用x射线晶体学的方法来确定所选系统的三维结构。我们正在研究大肠杆菌中参与转录激活的分子复合物：DNA、分解代谢基因激活蛋白和RNA聚合酶的α亚基。我们也在研究与甲型流感感染有关的RNA蛋白复合物。此外，我们正在确定选定的寡核苷酸的结构，试图了解序列和环境对DNA结构的影响。

The goal of this research is to determine the principles that underlie the interactions of key biological molecules. To do this, we will use the methods of x-ray crystallography to determine the three dimensional structures of selected systems. We are studying molecular complexes involved in the activation of transcription in E coli: DNA, the catabolite gene activator protein, and the alpha subunit of RNA polymerase. We are also studying RNA protein complexes that are involved in the influenza A infection. In addition, we are determining the structures of selected oligonucleotides in an attempt to understand the effects of sequence and environment on DNA structure.