Oklahoma Specialized Center of Research in SLE

俄克拉荷马州系统性红斑狼疮专业研究中心

• 批准号: 6531904
• 负责人: Morris Reichlin
• 金额: $ 115.5万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-05 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6531904
• 关键词: autoantibody; clinical research; human subject; systemic lupus erythematosus

DESCRIPTION (provided by applicant): The Oklahoma Medical Research Foundation proposes a Specialized Center of Research (SCOR) in systemic lupus erythematosus which will focus on understanding the roles of autoantibodies in SLE. The overarching goal of this center will be to integrate clinical rheumatic disease research with basic science investigators from throughout campus thereby strengthening basic science and patient oriented research in this state. Dr. Morris Reichlin is the Director, and he brings a distinguished career's worth of rheumatic disease research activities to this new integrated program. Briefly, this SCOR has five key investigators, five collaborating investigators (in-state), five collaborating investigators (out-of-state), nine additional arthritis investigators, fourteen basic science investigators, a Data and Analysis Core Director, Advisory Committee and a host of adjunct faculty, post-doctoral fellows, clinical fellows, MD-PhD students and graduate students. The key projects for this proposal include various approaches to understand how autoimmune responses start in SLE and how autoantibodies could lead to pathogenesis. The major projects in this SCOR will focus on understanding the development of autoantibodies with regards to symptom and SLE disease onset, exploring the role of autoantibodies in the development of dyslipidemias and accelerated cardiac disease, evaluating the basic role of B cell tolerance in the accrual of lupus autoantibodies, identifying potential etiologic triggers of these aberrant autoimmune responses and assessing the genetic predisposition to a severe serological and clinical SLE phenotype. A Data and Analysis Core and Administrative Core will support each of these individual projects. The primary Oklahoma SLE SCOR objectives are fourfold. First, this SCOR will strengthen research through integration of basic and clinical science in finding key etiological factors for SLE by supporting the above mentioned research projects. Second, biostatistical/research design issues will be incorporated into all ongoing rheumatic disease research in order to raise the current level of research activity. Third, key unique patient resources will be shared by several of the projects. Finally, this SCOR will provide a multidisciplinary structure and resources to strengthen current clinical rheumatic disease research through the influence of strong basic scientists involved in cardiovascular biology, lupus genetics, inflammation, coagulation, molecular biology, immunobiology, immunogenetics, clinical pharmacology and protein studies.

描述（由申请人提供）：俄克拉荷马州医学研究基金会提议设立一个系统性红斑狼疮专业研究中心 (SCOR)，该中心将重点了解自身抗体在 SLE 中的作用。该中心的总体目标是将临床风湿病研究与整个校园的基础科学研究人员整合起来，从而加强该州的基础科学和以患者为导向的研究。 Morris Reichlin 博士是主任，他为这个新的综合项目带来了风湿病研究活动的杰出职业价值。简而言之，该 SCOR 有 5 名关键研究人员、5 名合作研究人员（州内）、5 名合作研究人员（州外）、另外 9 名关节炎研究人员、14 名基础科学研究人员、一名数据和分析核心主任、顾问委员会以及许多兼职教师、博士后研究员、临床研究员、医学博士生和研究生。 该提案的关键项目包括了解系统性红斑狼疮中自身免疫反应如何启动以及自身抗体如何导致发病机制的各种方法。该 SCOR 的主要项目将侧重于了解自身抗体在症状和 SLE 疾病发作方面的发展，探索自身抗体在血脂异常和加速心脏病发展中的作用，评估 B 细胞耐受在狼疮自身抗体产生中的基本作用，识别这些异常自身免疫反应的潜在病因触发因素并评估 严重血清学和临床 SLE 表型的遗传倾向。数据和分析核心以及管理核心将支持每个单独的项目。 俄克拉荷马州 SLE SCOR 的主要目标有四个。首先，本次SCOR将通过支持上述研究项目，加强基础科学与临床科学相结合的研究，寻找SLE的关键病因。其次，生物统计/研究设计问题将被纳入所有正在进行的风湿病研究中，以提高当前的研究活动水平。第三，关键的独特患者资源将由多个项目共享。最后，该 SCOR 将提供多学科结构和资源，通过心血管生物学、狼疮遗传学、炎症、凝血、分子生物学、免疫生物学、免疫遗传学、临床药理学和蛋白质研究领域强大的基础科学家的影响力，加强当前的临床风湿病研究。