Sample Procurement and Management Core

采购和管理核心示例

• 批准号: 7938657
• 负责人: Morris Reichlin
• 金额: $ 11.71万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938657
• 关键词: Address; Autoantibodies; Autoimmune Process; Cells; Clinical; Clinical Data; Consent; Data; Databases; Enrollment; Goals; Housing; Human; Human Subject Research; Individual; Interdisciplinary Study; Laboratories; Life; Lupus; Measures; Methods; Oklahoma; Patients; Process; Quality Control; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Rheumatism; Sampling; Serum; Services; Systemic Lupus Erythematosus; Testing; Transformed Cell Line; data management; design; human subject; member; repository; research study; success

The goals of the Sample Procurement and Management Core (SPMC) are to optimize, promote and facilitate the research undertaken by the Center Investigators, as well as to enhance the interdisciplinary research capabilities between various Center laboratories and to expedite human subjects research in a meaningful way. The SPMC will provide support to Center Investigators and other users in terms of providing previously collected, de-identified, appropriately consented DMA and serum to projects, expanding DMA from existing resources or isolating additional DMA as needed from EBV-transformed cells lines, testing quality and quantity of outside and newly generated DMA and serum samples as needed, recruiting and enrolling fresh samples for project use, measuring autoantibodies in appropriate samples and managing samples and data for the success of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC). As potential collaborators for all Core research projects, the SPMC will be an integral part of the research team in the execution of research studies, as well as providing ongoing sample and data management throughout the life of each individual project. The specific goals of the SPMC include: 1. Facilitate access to human samples for research purposes. This goal includes serving as a central resource for Cores Center investigators to obtain appropriately collected DMA, serum, cells, clinical and de-identified clinical data. 2. Facilitate human subject consent, recruitment and compliance. This goal includes consenting, recruiting and obtaining samples from confirmation rheumatic disease patients for Core investigator projects, as well as assist with regulatory reporting. 3. Facilitate the compilation and appropriate access to de-identified patient demographic and clinical data from existing resources and management of research data for Center Investigators. Consent, recruit and/or obtain samples from confirmatory lupus subsets or from patients with other systemic autoimmune rheumatic diseases for feasibility and other projects for key Core investigators. 4. Perform autoantibody testing for appropriate rheumatic disease patient sera.

样本采购和管理核心（SPMC）的目标是优化， 促进和促进中心研究人员进行的研究，以及 增强各个中心实验室之间的跨学科研究能力 加快人类受试者以有意义的方式进行研究。 SPMC将为 中心调查人员和其他用户在提供先前收集，识别， 适当同意的DMA和血清项目，从现有资源中扩展DMA或 根据需要从EBV转换的单元线隔离其他DMA，测试质量和数量 根据需要的外部和新生成的DMA和血清样品的招募和注册 用于项目使用的新鲜样品，测量适当样品中的自身抗体并管理 俄克拉荷马州风湿病研究核心中心成功的样品和数据 （ORDRCC）。作为所有核心研究项目的潜在合作者，SPMC将是一个 研究团队的整体研究中的一部分在执行研究中，并提供 在每个项目的整个生命中，正在进行的样本和数据管理。 SPMC的具体目标包括： 1。促进用于研究目的的人类样本。这个目标包括 作为核心中心调查人员获得适当的中心资源 收集了DMA，血清，细胞，临床和去识别的临床数据。 2。促进人类的对象同意，招聘和合规性。这个目标包括 同意，招募和从确认风湿病中获得样本 核心调查员项目的患者以及协助监管报告。 3。促进汇编并适当访问去识别的患者 来自现有资源的人口统计和临床数据以及 中心研究人员的研究数据。同意，招募和/或从 确认性狼疮子集或其他全身自身免疫性风湿病患者 主要核心研究人员的可行性和其他项目的疾病。 4。对适当的风湿病患者血清进行自身抗体测试。