Sample Procurement and Management Core

采购和管理核心示例

• 批准号: 7938657
• 负责人: Morris Reichlin
• 金额: $ 11.71万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938657
• 关键词: Address; Autoantibodies; Autoimmune Process; Cells; Clinical; Clinical Data; Consent; Data; Databases; Enrollment; Goals; Housing; Human; Human Subject Research; Individual; Interdisciplinary Study; Laboratories; Life; Lupus; Measures; Methods; Oklahoma; Patients; Process; Quality Control; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Rheumatism; Sampling; Serum; Services; Systemic Lupus Erythematosus; Testing; Transformed Cell Line; data management; design; human subject; member; repository; research study; success

The goals of the Sample Procurement and Management Core (SPMC) are to optimize, promote and facilitate the research undertaken by the Center Investigators, as well as to enhance the interdisciplinary research capabilities between various Center laboratories and to expedite human subjects research in a meaningful way. The SPMC will provide support to Center Investigators and other users in terms of providing previously collected, de-identified, appropriately consented DMA and serum to projects, expanding DMA from existing resources or isolating additional DMA as needed from EBV-transformed cells lines, testing quality and quantity of outside and newly generated DMA and serum samples as needed, recruiting and enrolling fresh samples for project use, measuring autoantibodies in appropriate samples and managing samples and data for the success of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC). As potential collaborators for all Core research projects, the SPMC will be an integral part of the research team in the execution of research studies, as well as providing ongoing sample and data management throughout the life of each individual project. The specific goals of the SPMC include: 1. Facilitate access to human samples for research purposes. This goal includes serving as a central resource for Cores Center investigators to obtain appropriately collected DMA, serum, cells, clinical and de-identified clinical data. 2. Facilitate human subject consent, recruitment and compliance. This goal includes consenting, recruiting and obtaining samples from confirmation rheumatic disease patients for Core investigator projects, as well as assist with regulatory reporting. 3. Facilitate the compilation and appropriate access to de-identified patient demographic and clinical data from existing resources and management of research data for Center Investigators. Consent, recruit and/or obtain samples from confirmatory lupus subsets or from patients with other systemic autoimmune rheumatic diseases for feasibility and other projects for key Core investigators. 4. Perform autoantibody testing for appropriate rheumatic disease patient sera.

样品采购和管理核心 (SPMC) 的目标是优化、 促进和促进中心研究人员进行的研究，以及 增强各中心实验室之间的跨学科研究能力， 以有意义的方式加速人类受试者研究。 SPMC将提供支持 中心调查员和其他用户提供先前收集的、去识别化的、 适当同意项目的 DMA 和血清，从现有资源中扩展 DMA 或 根据需要从 EBV 转化细胞系中分离额外的 DMA，测试质量和数量 根据需要收集外部和新生成的 DMA 和血清样本，招募和登记 供项目使用的新鲜样品，测量适当样品中的自身抗体并进行管理 俄克拉荷马州风湿病研究核心中心成功的样本和数据 （ORDRCC）。作为所有核心研究项目的潜在合作者，SPMC 将成为 作为研究团队执行研究工作的重要组成部分，并提供 在每个项目的整个生命周期中持续进行样本和数据管理。 SPMC 的具体目标包括： 1. 促进出于研究目的获取人体样本。这个目标包括 作为核心中心调查人员获取适当信息的中央资源 收集 DMA、血清、细胞、临床和去识别化的临床数据。 2. 促进受试者同意、招募和合规。这个目标包括 同意、招募和获取确认风湿病样本 核心研究者项目的患者，以及协助监管报告。 3. 促进收集和适当访问未识别身份的患者 来自现有资源和管理的人口统计和临床数据 中心研究人员的研究数据。同意、招募和/或获取样本 确认性狼疮亚群或来自患有其他系统性自身免疫性风湿病的患者 关键核心研究人员的疾病可行性和其他项目。 4. 对适当的风湿病患者血清进行自身抗体检测。