Sample Procurement and Management Core

采购和管理核心示例

• 批准号: 7673677
• 负责人: Morris Reichlin
• 金额: $ 11.39万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7673677
• 关键词: Address; Autoantibodies; Autoimmune Process; Cells; Clinical; Clinical Data; Consent; Data; Databases; Enrollment; Goals; Housing; Human; Human Subject Research; Individual; Interdisciplinary Study; Laboratories; Life; Lupus; Measures; Methods; Oklahoma; Patients; Process; Purpose; Quality Control; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Rheumatism; Sampling; Serum; Services; Systemic Lupus Erythematosus; Testing; Transformed Cell Line; data management; design; human subject; member; repository; research study; success

The goals of the Sample Procurement and Management Core (SPMC) are to optimize, promote and facilitate the research undertaken by the Center Investigators, as well as to enhance the interdisciplinary research capabilities between various Center laboratories and to expedite human subjects research in a meaningful way. The SPMC will provide support to Center Investigators and other users in terms of providing previously collected, de-identified, appropriately consented DMA and serum to projects, expanding DMA from existing resources or isolating additional DMA as needed from EBV-transformed cells lines, testing quality and quantity of outside and newly generated DMA and serum samples as needed, recruiting and enrolling fresh samples for project use, measuring autoantibodies in appropriate samples and managing samples and data for the success of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC). As potential collaborators for all Core research projects, the SPMC will be an integral part of the research team in the execution of research studies, as well as providing ongoing sample and data management throughout the life of each individual project. The specific goals of the SPMC include: 1. Facilitate access to human samples for research purposes. This goal includes serving as a central resource for Cores Center investigators to obtain appropriately collected DMA, serum, cells, clinical and de-identified clinical data. 2. Facilitate human subject consent, recruitment and compliance. This goal includes consenting, recruiting and obtaining samples from confirmation rheumatic disease patients for Core investigator projects, as well as assist with regulatory reporting. 3. Facilitate the compilation and appropriate access to de-identified patient demographic and clinical data from existing resources and management of research data for Center Investigators. Consent, recruit and/or obtain samples from confirmatory lupus subsets or from patients with other systemic autoimmune rheumatic diseases for feasibility and other projects for key Core investigators. 4. Perform autoantibody testing for appropriate rheumatic disease patient sera.

样品采购和管理核心（SPMC）的目标是优化， 促进和促进中心研究者开展的研究，以及 加强各中心实验室之间的跨学科研究能力， 以一种有意义的方式加速人类受试者的研究。SPMC将提供支持， 中心研究者和其他用户在提供之前收集的、去识别的信息方面， 适当同意DMA和血清项目，扩大DMA从现有资源或 根据需要从EBV转化的细胞系中分离额外的DMA， 外部和新生成的DMA和血清样本（如需要），招募和入组 项目使用的新鲜样本，测量适当样本中的自身抗体， 俄克拉荷马州风湿病核心研究中心成功的样本和数据 （ORDRCC）。作为所有核心研究项目的潜在合作者，SPMC将是一个 研究团队的组成部分，在执行研究研究，以及提供 在每个项目的整个生命周期内持续进行样品和数据管理。 SPMC的具体目标包括： 1.为研究目的获取人体样本提供便利。这一目标包括 作为核心中心研究人员的中心资源， 收集DMA、血清、细胞、临床和去识别临床数据。 2.促进人类受试者同意、招募和依从性。这一目标包括 同意、招募和获取确认风湿性疾病的样本 核心研究者项目的患者，以及协助监管报告。 3.促进汇编和适当访问去识别患者 现有资源的人口统计学和临床数据， 研究中心研究者的研究数据。同意、招募和/或获取样本 或来自其他全身性自身免疫性风湿性关节炎患者 疾病的可行性和其他项目的关键核心研究人员。 4.对适当的风湿病患者血清进行自身抗体检测。