Sample Procurement and Management Core

采购和管理核心示例

• 批准号: 7325053
• 负责人: Morris Reichlin
• 金额: $ 9.8万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7325053
• 关键词: Address; Autoantibodies; Autoimmune Process; Cells; Clinical; Clinical Data; Consent; Data; Databases; Enrollment; Goals; Housing; Human; Human Subject Research; Individual; Interdisciplinary Study; Laboratories; Life; Lupus; Measures; Methods; Oklahoma; Patients; Process; Purpose; Quality Control; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Resources; Rheumatism; Sampling; Serum; Services; Systemic Lupus Erythematosus; Testing; Transformed Cell Line; data management; design; human subject; member; repository; research study; success

The goals of the Sample Procurement and Management Core (SPMC) are to optimize, promote and facilitate the research undertaken by the Center Investigators, as well as to enhance the interdisciplinary research capabilities between various Center laboratories and to expedite human subjects research in a meaningful way. The SPMC will provide support to Center Investigators and other users in terms of providing previously collected, de-identified, appropriately consented DMA and serum to projects, expanding DMA from existing resources or isolating additional DMA as needed from EBV-transformed cells lines, testing quality and quantity of outside and newly generated DMA and serum samples as needed, recruiting and enrolling fresh samples for project use, measuring autoantibodies in appropriate samples and managing samples and data for the success of the Oklahoma Rheumatic Disease Research Cores Center (ORDRCC). As potential collaborators for all Core research projects, the SPMC will be an integral part of the research team in the execution of research studies, as well as providing ongoing sample and data management throughout the life of each individual project. The specific goals of the SPMC include: 1. Facilitate access to human samples for research purposes. This goal includes serving as a central resource for Cores Center investigators to obtain appropriately collected DMA, serum, cells, clinical and de-identified clinical data. 2. Facilitate human subject consent, recruitment and compliance. This goal includes consenting, recruiting and obtaining samples from confirmation rheumatic disease patients for Core investigator projects, as well as assist with regulatory reporting. 3. Facilitate the compilation and appropriate access to de-identified patient demographic and clinical data from existing resources and management of research data for Center Investigators. Consent, recruit and/or obtain samples from confirmatory lupus subsets or from patients with other systemic autoimmune rheumatic diseases for feasibility and other projects for key Core investigators. 4. Perform autoantibody testing for appropriate rheumatic disease patient sera.

样品采购和管理核心(SPMC)的目标是优化、 促进和便利中心调查人员开展的研究，以及 加强各中心实验室之间的跨学科研究能力，并 以有意义的方式加快人类受试者的研究。SPMC将提供支持，以 中心调查人员和其他用户在提供以前收集的、未识别的、 适当地同意DMA和SERVER到项目，从现有资源或 根据需要从EBV转化的细胞系中分离额外的DNA，并进行质量和数量检测 根据需要对外部和新产生的DMA和血清样本进行招募和登记 用于项目使用的新鲜样本，测量适当样本中的自身抗体并管理 俄克拉荷马州风湿病研究中心成功的样本和数据 (ORDRCC)。作为所有核心研究项目的潜在合作者，SPMC将成为 研究团队在执行研究研究方面不可或缺的一部分，以及提供 在每个单独项目的整个生命周期内进行样本和数据管理。 小岛屿发展中国家特别委员会的具体目标包括： 1.为研究目的获取人体样本提供便利。这一目标包括 作为岩心中心调查人员适当获得的中心资源 收集DMA、血清、细胞、临床和未鉴定的临床数据。 2.促进人类受试者同意、招募和遵守。这一目标包括 同意、招募和获取确认风湿病的样本 为核心调查员项目的患者提供帮助，以及协助监管报告。 3.便利汇编和适当访问未确认身份的患者 来自现有资源和管理的人口统计和临床数据 中心调查人员的研究数据。同意、招募和/或获取样本 确诊狼疮亚群或来自其他系统性自身免疫性风湿病患者 疾病的可行性和关键核心研究人员的其他项目。 4.对适当的风湿病患者血清进行自身抗体检测。