Equipment Enhancement for NCV: P20RR 15635

NCV 设备增强：P20RR 15635

• 批准号: 6707304
• 负责人: Charles Wood
• 金额: $ 47.18万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6707304
• 关键词: Equipment; Enhancement; NCV; P20RR; 15635

DESCRIPTION (provided by applicant): This revised application for a COBRE supplement details a plan to upgrade shared instrumentation to support the Nebraska Center for Virology (NCV), an NIH-IDeA funded and designated Center of Biomedical Research Excellence. The long-term goal of the NCV is to become a nationally recognized center of excellence in virology research. The Center's objectives are to 1) conduct basic research addressing fundamental questions about the replication cycle of HIV, herpesviruses and other infectious agents and about host responses that may lead to pathological changes and 2) create an environment that wilt stimulate multi-discipline interactions to produce a new generation of innovative researchers with a much broader knowledge encompassing the entire field of virology. The Nebraska Center for Virology has made substantial progress toward its long-term goal and objectives during the past three years, but faces a barrier to continuing its momentum - a deficiency in certain large shared pieces of equipment, which negatively impacts NCV researchers and the Center's ability to recruit new hires. The objectives of this proposal are to purchase and replace major shared instrumentation to meet the needs of new NCV researchers, assist in the recruitment of promising researchers and to enhance biomedical research focusing on infectious diseases at the University of Nebraska-Lincoln. These objectives will be accomplished through a three-part specific aim: purchase major shared equipment items to support current Center faculty and to attract promising new researchers to the Center. The subaims are to purchase: (a) a confocal microscope for live-cell imaging, (b) a flow cytometer for sorting and analysis of virally infected cells and (c) a phosphorimaging system to replace an existing obsolete unit. Support for this revised application will ensure that the synergy that has resulted from the formation of the Nebraska Center for Virology will continue to elevate Nebraska biomedical research to the next level of excellence.

描述（由申请人提供）： COBRE补充的修订申请详细说明了升级共享仪器的计划，以支持内布拉斯加州病毒学中心（NCV），这是一个由NIH-IDEA资助并指定的生物医学研究卓越中心。NCV的长期目标是成为全国公认的病毒学研究卓越中心。该中心的目标是：1）进行基础研究，解决有关艾滋病毒，疱疹病毒和其他传染性病原体的复制周期以及可能导致病理变化的宿主反应的基本问题; 2）创造一个环境，刺激多学科互动，以培养新一代具有更广泛知识的创新研究人员，涵盖整个病毒学领域。在过去的三年里，内布拉斯加病毒学中心在实现其长期目标和目的方面取得了实质性进展，但仍面临着继续其发展势头的障碍-某些大型共享设备的不足，这对NCV研究人员和该中心招募新员工的能力产生了负面影响。该提案的目标是购买和更换主要的共用仪器，以满足新的NCV研究人员的需求，协助招聘有前途的研究人员，并加强内布拉斯加大学林肯分校以传染病为重点的生物医学研究。这些目标将通过三部分的具体目标来实现：购买主要的共享设备项目，以支持当前的中心教师，并吸引有前途的新研究人员到中心。次级目标是购买：（a）用于活细胞成像的共聚焦显微镜，（B）用于病毒感染细胞的分选和分析的流式细胞仪，和（c）用于替换现有的废弃单元的磷光成像系统。对这一修订后的申请的支持将确保内布拉斯加州病毒学中心的形成所产生的协同作用将继续将内布拉斯加州生物医学研究提升到下一个卓越水平。