FETAL AND NEONATAL CEREBRAL PHYSIOLOGY

描述（由申请人提供）：美国每年有12%的活产婴儿（470，000名婴儿）发生早产，是婴儿死亡和发病的主要原因，每年的医疗保健费用超过20亿美元。这种死亡率和长期发病率大部分是由围产期脑灌注和代谢紊乱引起的。尽管近年来存活早产儿的临床管理策略逐渐降低了脑血管病的发病率，但成人脑血管病的临床管理的重大改进一直缓慢，影响了新生儿脑损伤的研究。同样，最近在了解发育中的胎儿的心血管，免疫和内分泌稳态的基本机制方面的进展也很慢，在实践中的产科医生中找到了观众，特别是在高危早产儿方面。这些学科之间有限的思想转移率是广泛专业化的自然结果，并缩小了许多医学专家扩大临床责任的重点。因此，拟议的会议已被设计为汇集主要对新生儿脑血管病理生理学感兴趣的研究人员，科学家主要集中在成人脑血管调节的研究，以及科学家的专业知识中心在发育中的胎儿心血管，免疫和内分泌调节。为此，组织了一次围产期脑缺氧缺血学会、脑血流和代谢学会以及胎儿和新生儿生理学学会的联席会议。这次大型会议将涉及1000多个摘要和报告，其中要求支持一个专题讨论会（发育中白色物质的缺氧缺血性损伤）和三个主题演讲：围产期脑发育：历史回顾;胎儿心血管发育;和胎儿内分泌学的新概念。本次会议的背景是在加拿大卡尔加里，这将提供一个美丽和轻松的气氛充满了所有的设施和方便的主要国际化中心。组织者热情地期待，这次独特的联席会议将提供一个前所未有的机会，为有关胎儿脑血管调节和病理生理学的跨学科交流的想法。

DESCRIPTION (provided by applicant): Pre-term delivery occurs in 12% of live births (470,000 infants) in the United States each year, is a major cause of infant mortality and morbidity, and is associated with health care costs of more than $2 billion annually. Much of this mortality and long-term morbidity results from perinatal disturbances in cerebral perfusion and metabolism. Whereas strategies for clinical management of surviving pre-term infants have gradually reduced cerebrovascular morbidity in recent years, major improvements in clinical management of adult cerebrovascular pathologies have been slow to reach and influence studies of the neonatal cerebral injury. Similarly, recent advances in understanding of fundamental mechanisms of cardiovascular, immunological, and endocrine homeostasis in the developing fetus have also been slow to find an audience among practicing neonatologists, particularly where at-risk pre-term infants are concerned. These limited rates of idea transfer between disciplines are natural consequences of extensive specialization and narrowed focus secondary to expanding clinical responsibilities for many neonatologists. Accordingly, the proposed conference has been designed to bring together investigators interested mainly in neonatal cerebrovascular pathophysiology, with scientists focusing mainly on studies of adult cerebrovascular regulation, and scientists whose expertise centers on cardiovascular, immunological, and endocrine regulation in the developing fetus. To that end, a joint meeting of the Perinatal Cerebral Hypoxia-lschemia Society, the Society for Cerebral Blood Flow and Metabolism, and the Fetal and Neonatal Physiology Society has been organized. This large meeting will involve more than 1000 abstracts and presentations, among which support is requested for one symposium (Hypoxic-lschemic Damage in Developing White Matter) and three keynote lectures: Perinatal Brain Development: A Historical Overview; Fetal Cardiovascular Development; and New Concepts in Fetal Endocrinology. The setting for this conference is in Calgary, Canada, which will provide a beautiful and relaxing atmosphere replete with all the amenities and easy accessibility of a major cosmopolitan center. The organizers enthusiastically anticipate that this unique joint meeting will offer an unprecedented opportunity for an inter-disciplinary exchange of ideas related to fetal cerebrovascular regulation and pathophysiology.