FETAL AND NEONATAL CEREBRAL PHYSIOLOGY

描述（由申请人提供）：在美国，每年有12%的活产婴儿（470,000名婴儿）发生早产，是婴儿死亡和发病的主要原因，每年与医疗保健费用超过20亿美元相关。这种死亡率和长期发病率大多是由于围产期脑灌注和代谢紊乱造成的。近年来，对幸存早产儿的临床管理策略逐渐降低了脑血管发病率，但成人脑血管疾病的临床管理的重大改进却未能达到并影响新生儿脑损伤的研究。同样，最近对发育中的胎儿的心血管、免疫和内分泌平衡的基本机制的理解也进展缓慢，难以在执业的新生儿科医生中找到读者，特别是在有风险的早产儿中。这些学科之间有限的思想转移率是广泛的专业化和缩小焦点的自然结果，其次是扩大许多新生儿医生的临床责任。因此，本次会议旨在汇集主要对新生儿脑血管病理生理学感兴趣的研究人员，主要关注成人脑血管调节研究的科学家，以及以发育中的胎儿的心血管、免疫和内分泌调节为专业知识的科学家。为此，组织了围产期脑缺氧血症学会、脑血流和代谢学会以及胎儿和新生儿生理学学会的联合会议。这次大型会议将涉及1000多篇摘要和报告，其中要求支持一个研讨会（发育中的白质缺氧缺血性损伤）和三个主题演讲：围产期大脑发育：历史概述；胎儿心血管发育；胎儿内分泌学新概念。本次会议在加拿大卡尔加里举行，这里将提供一个美丽而轻松的氛围，拥有一个主要国际大都市的所有便利设施和交通便利。主办方热切期待这次独特的联合会议将为胎儿脑血管调节和病理生理学相关的跨学科思想交流提供前所未有的机会。

DESCRIPTION (provided by applicant): Pre-term delivery occurs in 12% of live births (470,000 infants) in the United States each year, is a major cause of infant mortality and morbidity, and is associated with health care costs of more than $2 billion annually. Much of this mortality and long-term morbidity results from perinatal disturbances in cerebral perfusion and metabolism. Whereas strategies for clinical management of surviving pre-term infants have gradually reduced cerebrovascular morbidity in recent years, major improvements in clinical management of adult cerebrovascular pathologies have been slow to reach and influence studies of the neonatal cerebral injury. Similarly, recent advances in understanding of fundamental mechanisms of cardiovascular, immunological, and endocrine homeostasis in the developing fetus have also been slow to find an audience among practicing neonatologists, particularly where at-risk pre-term infants are concerned. These limited rates of idea transfer between disciplines are natural consequences of extensive specialization and narrowed focus secondary to expanding clinical responsibilities for many neonatologists. Accordingly, the proposed conference has been designed to bring together investigators interested mainly in neonatal cerebrovascular pathophysiology, with scientists focusing mainly on studies of adult cerebrovascular regulation, and scientists whose expertise centers on cardiovascular, immunological, and endocrine regulation in the developing fetus. To that end, a joint meeting of the Perinatal Cerebral Hypoxia-lschemia Society, the Society for Cerebral Blood Flow and Metabolism, and the Fetal and Neonatal Physiology Society has been organized. This large meeting will involve more than 1000 abstracts and presentations, among which support is requested for one symposium (Hypoxic-lschemic Damage in Developing White Matter) and three keynote lectures: Perinatal Brain Development: A Historical Overview; Fetal Cardiovascular Development; and New Concepts in Fetal Endocrinology. The setting for this conference is in Calgary, Canada, which will provide a beautiful and relaxing atmosphere replete with all the amenities and easy accessibility of a major cosmopolitan center. The organizers enthusiastically anticipate that this unique joint meeting will offer an unprecedented opportunity for an inter-disciplinary exchange of ideas related to fetal cerebrovascular regulation and pathophysiology.