Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

 描述(申请人提供)：项目摘要(胰腺癌诊断和治疗策略中心)尽管在检测和治疗各种癌症方面取得了显著进展，但胰腺癌仍是美国男性和女性癌症相关死亡的主要原因之一，其5年存活率不到6%。胰腺癌与其他类型的癌症相比，缺乏早期症状、生存期短和治疗抵抗是其特点。这种严峻的形势迫切需要有效的治疗策略。我们建议在北达科他州立大学(NDSU)建立一个胰腺癌诊断和治疗策略中心。这个拟建的科布雷中心将在开发诊断和治疗工具方面进行合作的基础研究，这将导致胰腺癌的早期发现和治疗。该中心将由初级研究人员开发自给自足的研究计划，以增加NIH资助的研究拨款的数量，加强NDSU的基础设施以促进生物医学研究，并扩大该大学建立疾病专项计划的能力，特别是关于胰腺癌的计划。拟建的中心将在细胞和模型动物水平上进行胰腺癌检测和控制的内在基础研究，涉及一个由初级调查人员组成的多学科团队。初级调查员将利用这些资源 在拟议的行政和动物核心下开发。初级研究人员的科学实力将通过直接导师和研讨会系列与精英生物医学研究人员的直接互动来协同增强，他们将有能力获得NIH-R01拨款，从而获得独立研究地位。拟建的科布雷中心将有助于加强南大校园的基础设施，并支持生物医学研究。拟议研究的具体目标是：(1)开发成功的、独立的和自我维持的研究项目，吸引初级研究人员增加NDSU资助的NIH-R01拨款数量，(2)加强NDSU的基础设施以支持生物医学研究项目，以及(3)在NDSU建立国家认可的胰腺癌研究中心。这些目标将通过建立拟议的科布雷中心来实现，该中心将开发用于控制胰腺癌的发病和增殖的诊断和治疗工具。

 DESCRIPTION (provided by applicant): Project Summary (Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early symptoms, short survival, and resistance to therapy are hallmarks of pancreatic vis a vis other forms of cancer. This grim situation calls for the urgent need of effective therapeutic strategies. We are proposing to establish a Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at North Dakota State University (NDSU). This proposed COBRE center will conduct collaborative fundamental studies on developing diagnostic and therapeutic tools which will lead to early detection and treatment of pancreatic cancer. This Center will develop self-sustaining research programs by junior investigators to increase the number of NIH funded research grants, enhance the infrastructure of NDSU to promote biomedical research, and expand the University's capability to establish the disease specific program, particularly on pancreatic cancer. The proposed center will conduct fundamental studies intrinsic to the detection and control of pancreatic cancer at cellular and model animal levels involving a multidisciplinary team of junior investigators. The junior investigators will utilize the resources developed under the proposed Administrative and Animal Cores. The scientific strengths of junior investigators will be synergistically augmented by direct interaction with elite biomedical researchers via direct mentorship and seminar series, and they will become competent to obtain the NIH-R01 grant, leading to the attainment of independent research status. The proposed COBRE center will be instrumental in enhancing the infrastructure of the NDSU campus and support biomedical research. The specific aims of the proposed research are geared toward: (1) developing successful, independent, and self-sustaining research projects engaging junior investigators to increase the number of funded NIH-R01 grants at NDSU, (2) enhancing the infrastructure of NDSU to support biomedical research programs, and (3) establishing a nationally recognized center for pancreatic cancer research at NDSU. These aims will be accomplished by establishing the proposed COBRE center, which will develop diagnostic and therapeutic tools for controlling the onset and proliferation of pancreatic cancer.