Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

胰腺癌诊断和治疗策略中心

• 批准号: 8813058
• 负责人: Sanku Mallik
• 金额: $ 206.11万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813058
• 关键词: Animal Model; Animals; Biomedical Research; Brain; Breast; Cancer Center; Cancer Death Rates; Cancer Etiology; Cancer Patient; Cell model; Centers of Research Excellence; Cessation of life; Collaborations; Core Facility; Country; Data; Death Rate; Detection; Development; Diagnosis; Diagnostic; Disease; Early Diagnosis; Early treatment; Faculty; FarGo; Funding; Goals; Grant; Health; Health Personnel; Human; Individual; Industry; Journals; Lead; Lung; Malignant Neoplasms; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Mentors; Mentorship; Mission; Nature; North Dakota; Oncologist; Oncology Group; Operative Surgical Procedures; Pancreas; Pilot Projects; Publications; Publishing; Qualifying; Records; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Series; Staging; Survival Rate; Symptoms; Therapeutic; Time; Training Programs; Translational Research; United States National Institutes of Health; Universities; Woman; Work; anticancer research; base; career development; disorder control; fundamental research; graduate student; member; men; multidisciplinary; nanoparticle; programs; public health relevance; research facility; symposium; tenure track; therapy resistant; tool; trend

 DESCRIPTION (provided by applicant): Project Summary (Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early symptoms, short survival, and resistance to therapy are hallmarks of pancreatic vis a vis other forms of cancer. This grim situation calls for the urgent need of effective therapeutic strategies. We are proposing to establish a Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at North Dakota State University (NDSU). This proposed COBRE center will conduct collaborative fundamental studies on developing diagnostic and therapeutic tools which will lead to early detection and treatment of pancreatic cancer. This Center will develop self-sustaining research programs by junior investigators to increase the number of NIH funded research grants, enhance the infrastructure of NDSU to promote biomedical research, and expand the University's capability to establish the disease specific program, particularly on pancreatic cancer. The proposed center will conduct fundamental studies intrinsic to the detection and control of pancreatic cancer at cellular and model animal levels involving a multidisciplinary team of junior investigators. The junior investigators will utilize the resources developed under the proposed Administrative and Animal Cores. The scientific strengths of junior investigators will be synergistically augmented by direct interaction with elite biomedical researchers via direct mentorship and seminar series, and they will become competent to obtain the NIH-R01 grant, leading to the attainment of independent research status. The proposed COBRE center will be instrumental in enhancing the infrastructure of the NDSU campus and support biomedical research. The specific aims of the proposed research are geared toward: (1) developing successful, independent, and self-sustaining research projects engaging junior investigators to increase the number of funded NIH-R01 grants at NDSU, (2) enhancing the infrastructure of NDSU to support biomedical research programs, and (3) establishing a nationally recognized center for pancreatic cancer research at NDSU. These aims will be accomplished by establishing the proposed COBRE center, which will develop diagnostic and therapeutic tools for controlling the onset and proliferation of pancreatic cancer.

 描述（由适用提供）：尽管在各种癌症的检测和治疗方面取得了显着进步，但胰腺癌是胰腺癌的主要进步，但在美国，男性和女性的主要原因是，胰腺癌的主要原因之一是，在5年的5年生存率率少于6％。缺乏早期症状，短期生存和对治疗的抵抗是胰腺的标志，患有其他形式的癌症。这种严峻的情况要求迫切需要有效的治疗策略。我们建议在北达科他州立大学（NDSU）建立胰腺癌诊断和治疗策略中心。该拟议的山核桃中心将进行有关开发诊断和治疗工具的合作基础研究，这将导致胰腺癌的早期发现和治疗。该中心将开发初级研究人员自我维持的研究计划，以增加NIH资助的研究补助金的数量，增强NDSU的基础设施以促进生物医学研究，并扩大大学建立特定疾病计划的能力，尤其是在胰腺癌方面。拟议的中心将进行基本研究，用于在细胞和模型动物水平上检测和控制胰腺癌的固有研究，涉及一个初级研究者的多学科团队。初级调查人员将利用资源 根据拟议的行政和动物核心开发。初级研究者的科学优势将通过直接与精英生物医学研究人员通过直接训练和开创性系列的直接互动来协同增强，他们将有能力获得NIH-R01赠款，从而导致独立研究状况的归因。拟议的田园中心将有助于增强NDSU校园的基础设施并支持生物医学研究。拟议研究的具体目的旨在：（1）开发成功，独立和自我维持的研究项目，吸引初级研究人员增加NDSU资助的NIH-R01赠款的数量，（2）加强NDSU的基础设施以支持生物医学研究计划，并（3）建立一个国家认可的国家认可的中心，以建立pancreatic Cancer cancer Cancer cance ndsu.ndsu ndsu.ndsu。这些目标将通过建立拟议的毛病中心来实现，该中心将开发诊断和治疗工具来控制胰腺癌的发作和扩散。