Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

 描述（由申请人提供）：项目摘要（胰腺癌诊断和治疗策略中心）尽管在各种癌症的检测和治疗方面取得了显着进展，但胰腺癌是美国男性和女性癌症相关死亡的主要原因之一，5年生存率低于6%。缺乏早期症状、生存期短和对治疗的抵抗是胰腺维斯维斯其他形式癌症的标志。这种严峻的形势要求迫切需要有效的治疗策略。我们建议在北达科他州州立大学（NDSU）建立一个胰腺癌诊断和治疗策略中心。这个拟议中的COBRE中心将开展合作基础研究，开发诊断和治疗工具，从而早期发现和治疗胰腺癌。该中心将由初级研究人员开发自我维持的研究项目，以增加NIH资助的研究赠款的数量，加强NDSU的基础设施，以促进生物医学研究，并扩大大学建立疾病特异性项目的能力，特别是胰腺癌。该中心将在细胞和模型动物水平上进行胰腺癌检测和控制的基础研究，涉及多学科的初级研究人员团队。初级调查员将利用 根据拟议的行政和动物核心开发。初级研究人员的科学实力将通过直接指导和系列研讨会与精英生物医学研究人员直接互动来协同增强，他们将有能力获得NIH-R 01资助，从而获得独立研究地位。拟议中的COBRE中心将有助于加强NDSU校园的基础设施，并支持生物医学研究。拟议研究的具体目标是：（1）开发成功的，独立的，自我维持的研究项目，吸引初级研究人员，以增加NDSU资助的NIH-R 01赠款的数量，（2）加强NDSU的基础设施，以支持生物医学研究计划，以及（3）在NDSU建立一个国家认可的胰腺癌研究中心。这些目标将通过建立拟议的COBRE中心来实现，该中心将开发用于控制胰腺癌发病和增殖的诊断和治疗工具。

 DESCRIPTION (provided by applicant): Project Summary (Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early symptoms, short survival, and resistance to therapy are hallmarks of pancreatic vis a vis other forms of cancer. This grim situation calls for the urgent need of effective therapeutic strategies. We are proposing to establish a Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at North Dakota State University (NDSU). This proposed COBRE center will conduct collaborative fundamental studies on developing diagnostic and therapeutic tools which will lead to early detection and treatment of pancreatic cancer. This Center will develop self-sustaining research programs by junior investigators to increase the number of NIH funded research grants, enhance the infrastructure of NDSU to promote biomedical research, and expand the University's capability to establish the disease specific program, particularly on pancreatic cancer. The proposed center will conduct fundamental studies intrinsic to the detection and control of pancreatic cancer at cellular and model animal levels involving a multidisciplinary team of junior investigators. The junior investigators will utilize the resources developed under the proposed Administrative and Animal Cores. The scientific strengths of junior investigators will be synergistically augmented by direct interaction with elite biomedical researchers via direct mentorship and seminar series, and they will become competent to obtain the NIH-R01 grant, leading to the attainment of independent research status. The proposed COBRE center will be instrumental in enhancing the infrastructure of the NDSU campus and support biomedical research. The specific aims of the proposed research are geared toward: (1) developing successful, independent, and self-sustaining research projects engaging junior investigators to increase the number of funded NIH-R01 grants at NDSU, (2) enhancing the infrastructure of NDSU to support biomedical research programs, and (3) establishing a nationally recognized center for pancreatic cancer research at NDSU. These aims will be accomplished by establishing the proposed COBRE center, which will develop diagnostic and therapeutic tools for controlling the onset and proliferation of pancreatic cancer.