ALCOHOL EXPOSURE, SOCIAL BEHAVIOR, AND THE AMYGDALA

酒精暴露、社交行为和杏仁核

• 批准号: 6777094
• 负责人: JOAQUIN N LUGO
• 金额: $ 2.61万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6777094
• 关键词: Animalia; amygdala; behavior test; behavioral /social science research tag; developmental neurobiology; ethanol; neuropharmacology; social behavior

People with Fetal Alcohol Sydrome (FAS) are known to have cognitive deficits. However, in comparison to individuals with similar cognitive deficits but were not exposed to alcohol, FAS individuals show more deficits in social behavior. This observation and others have lead to the question of how alcohol affects social behavior. In addition, the amygdala is thought to play an important role in social behavior and is adversely affected by the perinatal-alcohol exposure. This research will investigate the effect of prenatal alcohol exposure during three trimester equivalents on the amygdala. Unbiased-stereology will be used to compare volume differences in the amygdala nuclei. It is goal of this experiment to provide evidence for a neural mechanism for the deficits induced by alcohol exposure during development. In addition, possible gender differences will also be investigated.

众所周知，患有胎儿酒精综合征(FAS)的人有认知缺陷。然而，与有类似认知缺陷但没有接触酒精的人相比，Fas患者在社会行为方面表现出更多的缺陷。这一观察和其他观察引出了酒精如何影响社会行为的问题。此外，杏仁核被认为在社会行为中发挥重要作用，并受到围产期酒精暴露的不利影响。这项研究将调查孕期酒精暴露对杏仁核的影响。无偏见的体视学将被用来比较杏仁核的体积差异。本实验的目的是为酒精暴露在发育过程中导致缺陷的神经机制提供证据。此外，还将调查可能存在的性别差异。

项目成果

Effect of amygdalar opioids on the anxiolytic properties of ethanol.

杏仁阿片类药物对乙醇抗焦虑特性的影响。

• DOI: 10.1111/j.1749-6632.2003.tb07102.x
• 发表时间: 2003
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Wilson,MarleneA;Burghardt,PaulR;LugoJr,JoaquinN;Primeaux,StefanyD;Wilson,StevenP
• 通讯作者: Wilson,StevenP

Alcohol exposure during development: analysis of effects on female sexual behavior.

发育过程中的酒精暴露：对女性性行为影响的分析。

• DOI: 10.1111/j.1530-0277.2007.00525.x
• 发表时间: 2007
• 期刊: Alcoholism, clinical and experimental research
• 作者: Gass,JustinT;Jenkins,WilliamJ;Marino,MelissaD;LugoJr,JoaquinN;Kelly,SandraJ
• 通讯作者: Kelly,SandraJ