Obesity and cardiac Risk in American Indian Children

美洲印第安儿童的肥胖和心脏病风险

• 批准号: 6769436
• 负责人: Alexandra K. Adams
• 金额: $ 11.25万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-12 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769436
• 关键词: Native Americans; cardiovascular disorder prevention; cardiovascular disorder risk; child (0-11); clinical research; disease /disorder prevention /control; early experience; family genetics; gene environment interaction; human subject; obesity; patient oriented research

DESCRIPTION (provided by applicant): Background: Childhood obesity is a significant risk factor for the development of adult obesity, cardiovascular disease (CVD), and diabetes. Recent studies suggest very high rates of obesity in American Indian (AI) children. Candidate: This K23 award will facilitate Dr. Alexandra Adams' development as a patient-oriented scientist with a long-term goal of becoming a high-quality, independent academic investigator who develops intervention strategies for prevention of obesity, CVD and diabetes in Al populations. Qualifications: Dr. Adams' unique qualifications for this K23 award include her medical training and a Ph.D. in nutritional science. Since joining the University of Wisconsin (UW) Family Medicine (DFM) clinical and research faculty in 1999, she has established a strong working relationship with Al communities in Wisconsin and has initiated a number of important collaborative studies with tribal communities. Environment: The DFM and Medical School are committed to Dr Adams' development as a patient-oriented scientist. This is reflected in strong support letters, senior research mentors involved with the project, written commitment from her Chair, GCRC support, and collaborative opportunities with other UW research teams in one of the strongest research environments in the US. Training: Dr. Adams will develop her career in patient-oriented research by obtaining advanced training in clinical research design, blostatistics, participatory research, ethics, writing skills, and advanced body composition techniques. As part of her K-23 plan, She will complete the UW Clinical Investigator Preparatory Pathway (CIPP K30 grant) as well as participate in courses, seminars and training activities. She will receive extensive group and one-on-one mentoring from a number of LTW senior NIH-funded scientists and Dr. Ann Macaulay, Director of the Kahnawake Schools Diabetes Prevention Program at McGill University. Research: Dr Adams is working on a three phase collaborative participatory research project with two WI tribal communities who have asked her to partner with them to reduce the disease burden in their communities by decreasing obesity and CVD risk factors in their children. She hypothesizes that the high prevalence of obesity in WI Al children, which places them at high risk for adult CVD and diabetes, begins early in childhood. Thus, obesity prevention efforts must be targeted early in childhood. The project will 1) assess obesity prevalence and cardiac risk factors in Al children ages 0-7, 2) conduct growth modeling of the familial and environmental determinants of obesity, and 3) work in partnership with the communities to design community-based early intervention strategies to prevent childhood obesity. Significance: With the assistance of the K23 award, Dr. Adams will develop and test interventions to prevent obesity in Al children and its sequelae; CVD and diabetes.

描述（由申请人提供）： 背景：儿童肥胖是成人肥胖发展的重要危险因素， 心血管疾病（CVD）和糖尿病。最近的研究表明，美国印第安人（AI）儿童的肥胖率非常高。候选人：这个K23奖将促进亚历山德拉亚当斯博士的 发展成为一个以病人为导向的科学家，长期目标是成为一个高质量的， 独立的学术研究者，负责制定干预策略， 肥胖、心血管疾病和糖尿病。资格：亚当斯博士的独特资格， 这个K23奖项包括她的医学培训和博士学位。在营养科学中。自从加入 1999年，她担任威斯康星州大学（UW）家庭医学（DFM）临床和研究教师，与威斯康星州的Al社区建立了牢固的工作关系，并与部落社区开展了一些重要的合作研究。环境：DFM和 医学院致力于亚当斯博士作为一个以病人为导向的科学家的发展。这是 反映在强有力的支持信，高级研究导师参与该项目，书面 她的主席的承诺，GCRC的支持，以及与其他UW的合作机会 研究团队在美国最强大的研究环境之一。培训：亚当斯博士将通过获得临床方面的高级培训， 研究设计，blostatistics，参与式研究，道德，写作技巧，和先进的身体 合成技术。作为她的K-23计划的一部分，她将完成UW临床研究员 预备课程（CIPP K30赠款）以及参加课程，研讨会和培训 活动她将接受来自多个LTW的广泛小组和一对一指导 NIH资助的高级科学家和Kahnawake学校主任Ann Macaulay博士 麦吉尔大学糖尿病预防项目。研究：亚当斯博士正在研究一个三 与两个WI部落社区合作参与研究项目， 请她与他们合作，通过以下方式减少社区的疾病负担： 降低儿童肥胖和心血管疾病风险因素。她推测， WI Al儿童的肥胖患病率，这使他们处于成人CVD的高风险中， 糖尿病，始于童年早期。因此，肥胖预防工作必须在早期就有针对性， 童年.该项目将1）评估Al儿童的肥胖患病率和心脏危险因素 年龄0-7，2）进行家庭和环境决定因素的生长模型， 肥胖，3）与社区合作，设计基于社区的早期 预防儿童肥胖的干预策略。意义：在K23的帮助下 亚当斯博士将开发和测试干预措施，以防止肥胖的儿童及其 后遗症; CVD和糖尿病。