Projections from the amygdala to the cortex: an EM study

这个项目的目的是在电子显微镜水平上描述非人类灵长类动物杏仁核和视觉新皮层之间的联系。杏仁核对情绪反应至关重要，它可能与各种疾病有关，包括癫痫和自闭症。虽然我们知道杏仁核和大脑皮层是紧密相连的，但对这些连接的突触组织却知之甚少。 将顺行示踪剂菜豆-白细胞凝集素（PHA-L）立体定位注射到成年雄性恒河猴的杏仁核中。 在电镜下观察杏仁核向颞下回TE区和枕叶皮质VI区的投射。前皮质区参与面部处理，并被认为接受来自杏仁核的强烈投射。 在研究的第二阶段，组织将用细小病毒抗体进行双重标记

The objective of this project is to describe, at the electron microscopic level ,the connection between the amygdala and the visual neocortex of non-human primates. The amygdala is essential for emotional response, and it may be involved in a variety of illnesses, including epilepsy and autism. While it known that the amygdala and the cortex are heavily interconnected, little is known concerning the synaptic organization of these connections. The anterograde tracer, Phaseolus vulgarie- leucoagglutinin (PHA-L), will be stereotaxically injected into the amygdala of adult male rhesus monkeys. The transported tracer will under the electron microscope to characterize the projections from the amygdala to area TE in the inferior temporal gyrus and VI in the occipital cortex. The former cortical areas is involved in facial processing and is known to receive strong projections from the amygdala. In second phase of the study, tissue will be double-labeled with an antibody to parva