Fatigue in HIV-Positive People

HIV 阳性人群的疲劳

• 批准号: 6841373
• 负责人: Julie V Barroso
• 金额: $ 46.99万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6841373
• 关键词: HIV infections; blood tests; cellular pathology; clinical research; cortisol; depression; fatigue; functional ability; hemoglobin; human subject; immune response; liver function; longitudinal human study; patient oriented research; psychometrics; sleep disorders; social psychology; stress; testosterone; thyroid function; virus load

DESCRIPTION (provided by applicant): Fatigue is the most frequent and debilitating complaint of HIV-positive people; it affects 20-69% of this population, limiting their ability to work, maintain relationships, and perform activities of daily riving. While current research identifies physiological and psychosocial correlates of fatigue in seropositive people, results are conflicting, measurement of fatigue has not been specific to HIV-positive patients, and the data have been collected contemporaneously or retrospectively so it is not possible to know if the physiological and psychosocial changes precede fatigue and its worsening. To better understand fatigue in HIV-positive people and identify predictors of its occurrence and change, we propose to conduct a prospective, longitudinal study to address three aims: 1) to determine the level, circumstances, and consequences of fatigue in a group of community-dwelling HIV-positive individuals; 2) to determine at baseline the relationship of personal, HIV-related, physiological, psychosocial, and sleep quality variables to fatigue in HIV positive individuals; and 3) to determine prospectively the relationship of personal and HIV-related variables, and changes in physiological, psychosocial, and sleep quality variables to chronicity of fatigue (percentage of visits fatigued, level of fatigue over time) in HIV-positive individuals. The primary variables to be examined are HIV viral load, CD4 count, CD8CD38 count, testosterone, hemoglobin, depression, stressful life events, and sleep quality. Secondary variables include measures of hepatic, thyroid, immunological, gonadal, and hematologic function as well as salivary cortisol and cellular injury. Secondary psychosocial variables include anxiety and social support. A cohort of 125 HIV-positive individuals will be studied over a 3-year period, with study visits every 6 months and fatigue data collected between study visits via mail. Participants will be recruited from two large university infectious diseases clinics, a health department clinic for HIV-positive people, and a community-based AIDS service organization. They will be seen at the Duke University GCRC for assessment of physiological parameters, blood draws, and questionnaire and interview administration. Data will be analyzed using mixed effects models and multiple regression techniques. Results from this study will be used to guide the development of interventions to prevent or ameliorate fatigue in seropositive individuals.

描述（由申请人提供）：疲劳是艾滋病毒阳性人群最常见和令人衰弱的抱怨；它影响了这些人群的20-69％，限制了他们工作，维持关系并执行日常竞选活动的能力。 尽管当前的研究确定了血清阳性人群疲劳的生理和心理社会相关性，但结果是矛盾的，疲劳的测量并非特定于HIV阳性患者，并且数据被同时或追溯地收集，因此不可能知道生理和心理变化是否在生理和心理变化之前疲劳和疲劳。 为了更好地了解艾滋病毒阳性人群的疲劳并确定其发生和变化的预测因素，我们建议进行一项前瞻性的纵向研究，以解决三个目标：1）确定一组社区居住的HIV HIV阳性个体的水平，情况和后果； 2）确定基线时，个人，与HIV相关，生理，心理和睡眠质量变量与艾滋病毒阳性个体疲劳的关系； 3）为了确定与个人和HIV相关变量的关系，以及生理，心理和睡眠质量变量的变化与疲劳的慢性（访问百分比疲劳的百分比，随着时间的推移疲劳程度）在HIV阳性个体中。要检查的主要变量是HIV病毒载荷，CD4计数，CD8CD38计数，睾丸激素，血红蛋白，抑郁症，压力寿命事件和睡眠质量。 次要变量包括肝，甲状腺，免疫学，性腺和血液学功能以及唾液皮质醇和细胞损伤的度量。 次要的社会心理变量包括焦虑和社会支持。 将在3年的时间内研究125个HIV阳性个体的队列，每6个月进行研究访问，并通过邮件进行研究访问之间收集疲劳数据。 参与者将从两个大型大学传染病诊所，一个针对HIV阳性人群的卫生部门诊所和一个基于社区的艾滋病服务组织招募。 他们将在杜克大学GCRC中看到它们，以评估生理参数，抽血以及问卷和访谈管理。 将使用混合效应模型和多重回归技术分析数据。 这项研究的结果将用于指导开发干预措施，以预防或改善血清阳性个体的疲劳。