K-SPACE TIME APPROACH TO MOTION SUPPRESSION IN MRI

MRI 运动抑制的 K 空间时间方法

• 批准号: 6790643
• 负责人: Yi Wang
• 金额: $ 33.6万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6790643
• 关键词: angiocardiography; bioimaging /biomedical imaging; clinical research; heart motion; human subject; image enhancement; magnetic resonance imaging; pulmonary respiration; swine; technology /technique development

DESCRIPTION (Verbatim from Applicant's Abstract): The broad objective of this research is to develop effective and efficient methods for suppressing motion artifacts in magnetic resonance imaging (MRI). A k-space time approach is proposed to allow systematic tracking of motion effects during image acquisition and to design effective methods for reducing motion effects in image data. The specific aims are: 1) Develop accurate motion measurement and correction; 2) Optimize view ordering; 3) Develop integrated methods to reduce effects of one-variable motion; and 4) Develop integrated methods to reduce effects of multi-variable motion. Motion artifacts are the most important factor limiting image quality in many MRI studies including cardiac MRI. Ghosting effects of motion have been fairly successfully suppressed with a combination of techniques, yet suppression of motion blurring continues to be elusive, limiting image resolution. This research develops the navigator strategy to reduce motion blurring. Complex physiological motions are decomposed into the global and local motion. Efficient k-space orbits sensitizing multiple components of the global motion are designed for navigator acquisition. The image effects of the global motion are measured and corrected using navigator echoes. The effects of the local motion are reduced through view ordering and gating. Correction, gating, and view ordering are synergistically integrated into image acquisition, overcoming their individual limitations and combining their individual advantages. This integrated approach will substantially improve both the effectiveness and efficiency of motion suppression in MRI. The developed motion suppression methods will be evaluated in coronary MR angiography for suppressing cardiac motion effects, respiratory motion effects, and both cardiac and respiratory motion effects simultaneously. Successful development of this research will result in motion resistant, high resolution, 3D coronary MR angiography.

描述(逐字摘自申请者摘要)：本报告的总体目标 研究是开发有效和高效的方法来抑制运动 磁共振成像中的伪影。一种k空间时间方法是 建议允许系统跟踪图像过程中的运动效果 获取并设计有效的方法来减少运动效果 图像数据。 其具体目标是：1)发展精确的运动测量和矫正； 2)优化视图排序；3)开发综合方法以减少 单变量运动；以及4)开发综合方法以减少 多变量运动。 在许多情况下，运动伪影是限制图像质量的最重要因素 核磁共振研究，包括心脏核磁共振。运动的鬼影效果相当不错 通过多种技术的组合成功地抑制了，但抑制了 运动模糊仍然难以捉摸，限制了图像分辨率。这 研究开发了减少运动模糊的导航器策略。复合体 将生理运动分解为全局运动和局部运动。 对全球运动的多个分量敏感的有效k空间轨道 是为获取导航器而设计的。全球运动的图像效果 使用导航仪回波进行测量和校正。地方性因素的影响 通过视图排序和选通来减少运动。校正、门控和 视图排序协同集成到图像采集中，克服了 他们的个人局限性和结合他们的个人优势。这 综合方法将大大提高效率和 运动抑制在MRI中的效率。 开发的运动抑制方法将在冠状动脉MR中进行评估 用于抑制心脏运动、呼吸运动影响的血管造影术， 心脏运动和呼吸运动同时起作用。成功 这项研究的发展将导致抗动、高分辨率、 3D冠状动脉磁共振血管成像。