Dysphagia in Induced Parkinson's Disease

描述（申请人提供）：帕金森病在老年人中发病率高（Kondziolka et al., 1999; Shulz and Grant, 2000）。吞咽困难，吞咽异常，是帕金森病的一个重要组成部分（Basset, 1999； Bushman等，1989；Nagaya等，1998;Logemann, 1998； Potulska等，1999），影响营养、生活质量，最重要的是影响气道保护。鉴于人体功能障碍数据的获取不可避免地受到限制，帕金森病患者吞咽的定量运动学数据有限（如Wintzen等，1994）。对正常吞咽至关重要的肌肉的同步肌电图数据，虽然对表征运动模式和最终对吞咽的神经控制至关重要，但实际上不可能从正常或帕金森患者身上收集到。在过去的20年里，我们的研究小组在分析动物模型口腔和咽功能的运动学和运动模式方面积累了广泛的专业知识，最终目标是更好地理解人类功能障碍。最近在猪中化学诱导帕金森病模型的发展为我们提供了一个明显的机会，将我们的方法和经验应用于与这种疾病实体相关的喂养问题。本研究的目的是在帕金森氏病猪模型中收集初步数据，通过将其与我们广泛的正常功能对照数据进行比较，确定吞咽不同阶段功能障碍的程度。我们将使用我们成熟的同步放射成像和肌电图技术来建立这个模型的实用性。我们的最终目标是利用这些数据来制定R01方案，旨在系统地表征帕金森病对正常口腔和咽吞咽功能的破坏。

DESCRIPTION (provided by applicant): Parkinson's Disease occurs with high incidence in the elderly (Kondziolka et al., 1999; Shulz and Grant, 2000). Dysphagia, abnormal swallowing, is a significant component of Parkinson's disease (Basset, 1999; Bushman et al., 1989; Nagaya et al., 1998; Logemann, 1998; Potulska et al., 1999), impacting on nutrition, quality of life, and most significantly, airway protection. Given the inevitable restrictions on the acquisition of human dysfunction data, there are limited data on the quantitative kinematics of swallowing in patients with Parkinson's Disease (e.g. Wintzen et al., 1994). Synchronous electromyographic data from the muscles critical for normal deglutition, while essential for characterizing the motor patterns, and ultimately the neural control of swallowing, are virtually impossible to collect from either normal or Parkinsonian human subjects. Over the last 20 years, our research group has developed extensive expertise in analyzing the kinematics and motor pattern of oral and pharyngeal function in animal models with the ultimate goal of a better understanding of human dysfunction. The recent development of a chemically induced model of Parkinson's Disease in pigs presents an obvious opportunity for us to bring our methods and experience to bear on the feeding problems associated with this disease entity. The aim of this study is to collect preliminary data, in the pig model of Parkinson's Disease, to establish the extent of dysfunction in the different phases of swallowing by comparing them with our extensive control data on normal function. We will use our proven techniques of synchronized videoradiography and electromyography to establish the utility of this model. Our ultimate goal is to use these data for the development of an R01 proposal aimed at the systematic characterization of the Parkinsonian disruption of normal oral and pharyngeal swallowing function.