Dysphagia in Induced Parkinson's Disease

描述（由申请人提供）：帕金森病在老年人中发生率高（Kondziolka等人，1999; Shulz and Grant，2000）.吞咽困难、异常吞咽是帕金森病的重要组成部分（Basset，1999; Bushman等人，1989; Nagaya等人，1998; Logemann，1998; Potulska等人，1999年），影响营养，生活质量，最重要的是，气道保护。鉴于对人类功能障碍数据的获取的不可避免的限制，关于帕金森病患者吞咽的定量运动学的数据有限（例如，Wintzen等人，1994年）。来自正常吞咽关键肌肉的同步肌电图数据，虽然对于表征运动模式以及最终吞咽的神经控制至关重要，但实际上不可能从正常或帕金森病人类受试者中收集。 在过去的20年里，我们的研究小组在分析动物模型中口腔和咽功能的运动学和运动模式方面积累了丰富的专业知识，最终目标是更好地了解人类功能障碍。最近开发的化学诱导模型帕金森病的猪提出了一个明显的机会，我们把我们的方法和经验，承担与这种疾病的实体相关的饲养问题。 本研究的目的是收集初步的数据，在帕金森氏病的猪模型中，通过将它们与我们广泛的正常功能对照数据进行比较，来确定吞咽不同阶段的功能障碍程度。我们将使用我们的同步视频放射成像和肌电图证明技术，以建立该模型的实用性。我们的最终目标是使用这些数据的发展R 01的建议，旨在系统的帕金森氏症中断正常的口腔和咽吞咽功能的特点。

DESCRIPTION (provided by applicant): Parkinson's Disease occurs with high incidence in the elderly (Kondziolka et al., 1999; Shulz and Grant, 2000). Dysphagia, abnormal swallowing, is a significant component of Parkinson's disease (Basset, 1999; Bushman et al., 1989; Nagaya et al., 1998; Logemann, 1998; Potulska et al., 1999), impacting on nutrition, quality of life, and most significantly, airway protection. Given the inevitable restrictions on the acquisition of human dysfunction data, there are limited data on the quantitative kinematics of swallowing in patients with Parkinson's Disease (e.g. Wintzen et al., 1994). Synchronous electromyographic data from the muscles critical for normal deglutition, while essential for characterizing the motor patterns, and ultimately the neural control of swallowing, are virtually impossible to collect from either normal or Parkinsonian human subjects. Over the last 20 years, our research group has developed extensive expertise in analyzing the kinematics and motor pattern of oral and pharyngeal function in animal models with the ultimate goal of a better understanding of human dysfunction. The recent development of a chemically induced model of Parkinson's Disease in pigs presents an obvious opportunity for us to bring our methods and experience to bear on the feeding problems associated with this disease entity. The aim of this study is to collect preliminary data, in the pig model of Parkinson's Disease, to establish the extent of dysfunction in the different phases of swallowing by comparing them with our extensive control data on normal function. We will use our proven techniques of synchronized videoradiography and electromyography to establish the utility of this model. Our ultimate goal is to use these data for the development of an R01 proposal aimed at the systematic characterization of the Parkinsonian disruption of normal oral and pharyngeal swallowing function.