Host-Microbe Interactions

宿主-微生物相互作用

• 批准号: 6789391
• 负责人: RONALD K TAYLOR
• 金额: $ 25.54万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6789391
• 关键词: Host; Microbe; Interactions

DESCRIPTION (provided by applicant): The primary goals of the proposed training program are first to recruit talented and highly motivated graduate students and postdoctoral fellows and second to provide them with first-rate training which will prepare them for careers in academic research as competitive, independent investigators. The program faculty's research interests span a wide range of questions regarding host-microbe interactions and related topics in pathogenesis, which allows the entering trainee a considerable breadth of choice of experimental systems, approaches, and research topics. Training options include animal and human systems, thus enhancing our ability to attract and train M.D.'s for research careers. Another strength of the proposed training grant is the quality of the research programs of the participating faculty. This proposal includes 13 well-funded program faculty members who have productive, timely, and energetic research efforts in numerous areas of current interest. Particular areas of strength are molecular genetics of bacterial, parasitic, and viral pathogenesis; cellular and immunobiology of parasites; B cell activation and interaction with T helper cells and lymphokines; mucosal immune responses; signaling events in host-pathogen interactions; involvement of various immune mechanisms in resistance to infectious diseases including those caused by parasites, bacteria, and retroviruses such as HIV and mouse AIDS (MAIDS) virus; immunotherapeutics and vaccine design. These areas are pursued using the full range of modem genetic, immunologic, biochemical, and molecular biologic techniques. We have excellent facilities, including new laboratories in the Borwell Research Building constructed in 1992. The proposal also benefits from the presence of strong existing graduate programs leading to the Ph.D. degree. Training in molecular pathogenesis spans six departments that encompass two graduate programs - Physiology, and Molecular and Cellular Biology - with the latter containing the majority of the participating faculty and students. Consistent with this organization, graduate training in molecular pathogenesis at Dartmouth is an interdisciplinary approach that is nurtured by a highly interactive environment in which the trainees are regularly exposed to diverse areas of faculty expertise, from clinical to basic science studies, in a variety of forums, including a number of advanced courses, weekly seminar series and journal clubs, and retreats. By these means our trainees benefit from a vigorous faculty involvement and scientific exchange that results in maximized communication of their work, the program faculty's work, and the progress of the various interdisciplinary fields on the international level.

描述（由申请人提供）：拟议培训计划的主要目标首先是招募有才华且积极进取的研究生和博士后研究员，其次为他们提供一流的培训，为他们作为有竞争力的独立研究人员从事学术研究职业做好准备。该项目教师的研究兴趣涵盖有关宿主-微生物相互作用和发病机制相关主题的广泛问题，这使得进入的实习生可以在实验系统、方法和研究主题上有相当广泛的选择。培训选项包括动物和人体系统，从而增强我们吸引和培训医学博士从事研究职业的能力。拟议培训补助金的另一个优势是参与教师的研究项目的质量。该提案包括 13 名资金充足的项目教员，他们在当前感兴趣的众多领域做出了富有成效、及时且充满活力的研究工作。特别擅长的领域是细菌、寄生虫和病毒发病机制的分子遗传学；寄生虫的细胞和免疫生物学； B 细胞激活以及与 T 辅助细胞和淋巴因子的相互作用；粘膜免疫反应；宿主与病原体相互作用中的信号事件；各种免疫机制参与抵抗传染病，包括由寄生虫、细菌和逆转录病毒（例如艾滋病毒和小鼠艾滋病（MAIDS）病毒）引起的疾病；免疫治疗和疫苗设计。这些领域是利用全方位的现代遗传学、免疫学、生物化学和分子生物学技术来研究的。我们拥有一流的设施，包括 1992 年在 Borwell 研究大楼内建造的新实验室。该提案还受益于现有的强大的研究生项目，可通往博士学位。程度。分子发病机制的培训跨越六个系，包括两个研究生项目——生理学、分子和细胞生物学——其中大多数参与的教职员工和学生都在后者中。与该组织一致，达特茅斯的分子发病机制研究生培训是一种跨学科方法，由高度互动的环境培育，学员定期在各种论坛中接触从临床到基础科学研究的不同领域的教师专业知识，包括许多高级课程、每周研讨会系列和期刊俱乐部以及静修会。通过这些方式，我们的学员受益于教师的积极参与和科学交流，从而最大限度地交流他们的工作、项目教师的工作以及国际水平上各个跨学科领域的进展。