Host-Microbe Interactions

描述（由申请人提供）：本申请要求支持继续“宿主-微生物相互作用”博士前培训计划，该计划是达特茅斯著名的微生物学和分子发病机制计划（M2P2）的核心。M2P2是一个跨学科项目，包括来自达特茅斯Geisel医学院和达特茅斯学院4个部门的教师调查人员。培训计划旨在为我们的培训师实验室招募的一群有才华和高度上进心的学生提供研究和课程培训。M2P2对达特茅斯生物医学研究界的贡献是全面而重要的，这反映在2010年对更大的研究生项目的外部审查的最终报告中。评审人员评论说，M2P2教师的主动性和成功是值得注意的，他们做出了实质性的贡献，特别是在课程开发、学生招聘和机构推广方面，使整个项目受益。M2P2由20名资金充足的培训师（2013年的直接成本为1560万美元）组成，他们的实验室目前总共有60名学员。我们要求维持目前每年5名受训人员的支助水平。培训包括分子，微生物，动物，人类和生物信息学系统，这为我们的学员提供了广泛的研究和丰富的机会。特定领域的优势包括细菌，真菌，寄生虫和病毒发病机理的分子遗传学，B细胞活化和与T辅助细胞的相互作用，T细胞活性的调节，粘膜免疫反应，宿主-病原体相互作用的信号事件，持续感染期间的病毒-宿主相互作用，囊性纤维化，以及治疗和疫苗设计的应用。这些领域是利用现代遗传、分子、生化、免疫学和生物信息学技术进行的。这项工作是在优秀的最先进的设施中进行的，在一个愉快的工作环境中，现代化的空间里安置了资源。达特茅斯已经并将继续大力投资其生物医学科学基础设施，在该培训计划的上一个资助期内，新建设资金为1.95亿美元，翻新资金为3600万美元。2013年又开始了1.15亿美元的新建设。在这个项目中训练的学生是从分子和细胞生物学（MCB）多学科研究生项目中挑选出来的，这是达特茅斯最大的研究生项目。学生在这个高度互动的环境中培养，所有学员都参加一个核心课程

DESCRIPTION (provided by applicant): This application requests support to continue the "Host-Microbe Interactions" predoctoral training program that is the centerpiece of the acclaimed Microbiology and Molecular Pathogenesis Program (M2P2) at Dartmouth. M2P2 is an interdisciplinary program that includes faculty investigators from 4 departments in the Geisel School of Medicine at Dartmouth and Dartmouth College. The training program seeks to provide research and curricular-based training to a pool of talented and highly motivated students that have been recruited into our trainers' labs. The contribution of M2P2 to the Dartmouth biomedical research community has been overarching and significant as is reflected in the final report of a 2010 external review of the larger graduate program. The reviewers commented that the initiative and success of the M2P2 faculty is noteworthy, having made substantial contributions, particularly in the areas of curriculum development, student recruitment, and institutional outreach that benefited the entire program. M2P2 consists of 20 well-funded trainers ($15.6M direct costs in 2013) who collectively currently have 60 trainees in their labs. We request to continue the present level of support of 5 trainees per year. Training includes molecular, microbial, animal, human, and bioinformatics systems, which provides our trainees with a wide breadth of research and enrichment opportunities. Particular areas of strength include molecular genetics of bacterial, fungal, parasitic, and viral pathogenesis, B cell activation and interaction with T helper cells, regulation of T cell activity, mucosal immune responses, signaling events in host-pathogen interactions, viral-host interactions during sustained infection, cystic fibrosis, and applications to therapeutic and vaccine design. These areas are pursued using the full range of modern genetic, molecular, biochemical, immunologic, and bioinformatics techniques. This work is conducted in outstanding state-of-the art facilities with resources housed in modern space in a pleasant working environment. Dartmouth has invested and continues to invest heavily in its biomedical sciences infrastructure with $195M of new construction and $36M of renovations completed during the previous funding period of this training program. An additional $115M of new construction began in 2013. Students to be trained in this program are selected from the Molecular and Cellular Biology (MCB) multidisciplinary graduate program, which is the largest graduate program at Dartmouth. Students are nurtured in this highly interactive environment in which all trainees enroll in a core course, several courses in ethics, and several advanced courses and career development workshops pertinent to their area of research training. In addition they participate in weekly seminar series and journal clubs, and present their work at joint lab meetings and retreats, and an annual MCB-wide Research in Progress (RIP) presentation. Our trainees supported specifically by the T32 are also provided with a series of additional enrichment activities described in Research Training Program Plan section 2.3E.