Research on the Scope and Causes of Stillbirth in the US

描述（由申请人提供）：本提案证明了埃默里大学医学院和公共卫生学院以及由6家医院组成的大都会亚特兰大死产研究联盟（MASSC）参与NICHD倡议的能力和承诺，以研究美国死产的范围和原因。MASSC代表学术、私营和公共部门，每年在这些医院分娩近40 000例。在DeKalb、富尔顿和Gwinnett县的100个人口普查区的集水区，90%以上的妇女在这些医院之一分娩（每年分娩9 000多例）。集水区的人口在种族、民族和经济上是多样化的。从1995年至1999年，集水区有280名妇女在卫生和社会服务部医院分娩了妊娠期超过20周的死胎（每1 000名分娩中有7.7名死胎超过20周）。产前护理，产妇种族，胎龄，死亡原因的数据，并与整个3县地区，5县地区的大都会亚特兰大出生缺陷监测计划，和国家的格鲁吉亚。提出了一项加强现有围产期数据系统的计划。多学科的研究小组包括来自埃默里医学院和公共卫生学院、美国疾病控制和预防中心以及格鲁吉亚人力资源部的科学家。他们为这项研究带来了广泛的专业知识，包括儿科/产科、产科/围产期、流行病学/公共卫生、儿科/围产期病理学、胎盘功能、传染病、血液学、遗传学、出生缺陷和神经学/神经病理学。该小组在相关领域的成功资助研究、出版物以及积极参与其他多中心研究和多中心网络方面有着悠久的历史。B医生。Stoll（PI）是国际公认的临床和流行病学研究者。她是埃默里大学NICHD新生儿研究网络的PI，也是医学研究所委员会“改善发展中国家的出生结果”的联合主席。“Carol Hogue博士（共同PI）是国际公认的生殖健康流行病学家和多中心合作研究的PI。提出了一个概念提案“死产与母亲和胎儿血栓形成倾向基因型的关联”。研究人员致力于与其他临床中心和科学团体合作，以实现NICHD死产网络的目标。

DESCRIPTION (provided by applicant): This proposal demonstrates the ability and commitment of the Emory University Schools of Medicine and Public Health and The Metropolitan Atlanta Stillbirth Study Coalition (MASSC), a consortium of 6 hospitals, to participate in the NICHD initiative to study the scope and causes of stillbirth in the United States. The MASSC represents the academic, private and public sectors, with almost 40,000 deliveries/year at these hospitals. Over 90% of women who live in a Catchment Area of 100 Census Tracts in DeKalb, Fulton and Gwinnett Counties deliver in one of these hospitals (over 9000 deliveries/year). Population in the Catchment Area is racially, ethnically, and economically diverse. From 1995-99, 280 women in the Catchment Area delivered a stillbirth of > 20 weeks' gestation in MASSC hospitals (7.7 stillbirths per 1,000 deliveries > 20 wks). Data on prenatal care, maternal race, gestational age, cause of death are presented and compared to the entire 3-County area, the 5-County area of the Metropolitan Atlanta Birth Defects Monitoring Program, and the State of Georgia. A plan to enhance the existing perinatal data system is presented. The multidisciplinary team of investigators includes scientists from the Emory Schools of Medicine and Public Health, U.S. Centers for Disease Control and Prevention, and Georgia Department of Human Resources. They bring a breadth of expertise to this study that includes pediatrics/neonatology, obstetrics/perinatology, epidemiology/public health, pediatric/perinatal pathology, placental function, infectious diseases, hematology, genetics, birth defects, and neurology/neuropathology. The group has a long history of successful funded research, publications in relevant areas, and active involvement with other multicenter studies and multicenter Networks. Dr. B. Stoll (PI) is an internationally recognized clinical and epidemiologic investigator. She is the PI at Emory for the NICHD Neonatal Research Network and co-chair of an Institute of Medicine committee, "Improving Birth Outcomes in Developing Countries." Dr Carol Hogue (co-PI) is an internationally recognized reproductive health epidemiologist and PI of multicenter collaborative studies. A concept proposal, "The association of stillbirths with maternal and fetal thrombophilia genotypes," is presented. The investigators are committed to working collaboratively with other clinical centers and scientific groups to achieve the goals of the NICHD Stillbirth Network.