Research on the Scope and Causes of Stillbirth in the US

描述（由申请人提供）：该提案证明了埃默里大学医学院和公共卫生学院以及亚特兰大大都会死产研究联盟（MASSC）的能力和承诺，该联盟由6家医院组成，参与NICHD倡议，研究美国死产的范围和原因。MASSC代表学术、私营和公共部门，每年在这些医院接生近40 000人。生活在迪卡尔布、富尔顿和格威内特县100个人口普查区集水区的妇女中，90%以上在这些医院之一分娩（每年分娩9000多例）。集水区的人口在种族、民族和经济上是多样化的。从1995年至1999年，汇水区有280名妇女在麻州社区医院分娩了妊娠100至20周的死胎（每1,000名妊娠100至20周的分娩中有7.7名死胎）。有关产前护理、产妇种族、胎龄、死亡原因的数据被呈现出来，并与整个3个县地区、亚特兰大大都会出生缺陷监测计划的5个县地区和佐治亚州进行了比较。提出了一项改进现有围产期数据系统的计划。多学科研究小组包括来自埃默里医学院和公共卫生学院、美国疾病控制和预防中心以及乔治亚州人力资源部的科学家。他们为这项研究带来了广泛的专业知识，包括儿科/新生儿学、产科/围产期学、流行病学/公共卫生、儿科/围产期病理学、胎盘功能、传染病、血液学、遗传学、出生缺陷和神经病学/神经病理学。该组织在成功资助的研究、相关领域的出版物以及积极参与其他多中心研究和多中心网络方面有着悠久的历史。B. Stoll博士（PI）是国际公认的临床和流行病学研究者。她是埃默里大学NICHD新生儿研究网络的首席研究员，也是医学研究所“改善发展中国家的出生结果”委员会的联合主席。Carol Hogue博士是国际公认的生殖健康流行病学家和多中心合作研究的PI。一个概念的建议，“死产与母体和胎儿的血栓病基因型的关联，”提出。研究人员致力于与其他临床中心和科学团体合作，以实现NICHD死产网络的目标。

DESCRIPTION (provided by applicant): This proposal demonstrates the ability and commitment of the Emory University Schools of Medicine and Public Health and The Metropolitan Atlanta Stillbirth Study Coalition (MASSC), a consortium of 6 hospitals, to participate in the NICHD initiative to study the scope and causes of stillbirth in the United States. The MASSC represents the academic, private and public sectors, with almost 40,000 deliveries/year at these hospitals. Over 90% of women who live in a Catchment Area of 100 Census Tracts in DeKalb, Fulton and Gwinnett Counties deliver in one of these hospitals (over 9000 deliveries/year). Population in the Catchment Area is racially, ethnically, and economically diverse. From 1995-99, 280 women in the Catchment Area delivered a stillbirth of > 20 weeks' gestation in MASSC hospitals (7.7 stillbirths per 1,000 deliveries > 20 wks). Data on prenatal care, maternal race, gestational age, cause of death are presented and compared to the entire 3-County area, the 5-County area of the Metropolitan Atlanta Birth Defects Monitoring Program, and the State of Georgia. A plan to enhance the existing perinatal data system is presented. The multidisciplinary team of investigators includes scientists from the Emory Schools of Medicine and Public Health, U.S. Centers for Disease Control and Prevention, and Georgia Department of Human Resources. They bring a breadth of expertise to this study that includes pediatrics/neonatology, obstetrics/perinatology, epidemiology/public health, pediatric/perinatal pathology, placental function, infectious diseases, hematology, genetics, birth defects, and neurology/neuropathology. The group has a long history of successful funded research, publications in relevant areas, and active involvement with other multicenter studies and multicenter Networks. Dr. B. Stoll (PI) is an internationally recognized clinical and epidemiologic investigator. She is the PI at Emory for the NICHD Neonatal Research Network and co-chair of an Institute of Medicine committee, "Improving Birth Outcomes in Developing Countries." Dr Carol Hogue (co-PI) is an internationally recognized reproductive health epidemiologist and PI of multicenter collaborative studies. A concept proposal, "The association of stillbirths with maternal and fetal thrombophilia genotypes," is presented. The investigators are committed to working collaboratively with other clinical centers and scientific groups to achieve the goals of the NICHD Stillbirth Network.