RUPP-PI

描述(由申请人提供)：这份U10提案，匹兹堡的RUPP-PI将在匹兹堡建立一个NIMH研究单位，用于儿科精神药理学-心理社会干预。建议设立的单位建立在匹兹堡办事处在情绪障碍和自杀行为的临床流行病学、心理社会治疗的开发、SSRI的药代动力学以及参与许多成功进行的涉及CBT、抗抑郁药及其组合治疗情绪和焦虑障碍的单地点和多地点临床试验方面的优势。支持这一研究和培训计划的资源包括儿童精神病学研究的T32博士后培训补助金，早发性情绪和焦虑症干预研究中心，致力于抗抑郁药药代动力学的RUPP，以及国家支持的情绪障碍和自杀行为专业诊所。示范研究方案《青少年自杀未遂者的治疗》(TASA)针对的是一个主要的公共卫生问题：尽管这个国家的青少年每年有200万次自杀未遂，但还没有针对这种情况进行大规模、多模式的控制干预研究。这项拟议的为期5年的研究将确定多模式治疗干预的有效性，以防止在8个地点对480名12岁至18岁的抑郁症青少年尝试再次尝试。实验治疗组将接受为期24周的抗抑郁药物管理(MM)和认知行为治疗。对照治疗组将被转介给社区提供者，提供标准的临床护理以及加强的临床监测和病例管理，以鼓励坚持治疗。两组都将在基线2周、4周、8周、12周、24周、36周和48周由独立评估者进行评估，而不考虑治疗分配。我们假设，在为期一年的观察期内，实验性治疗将导致自杀企图减少，抑郁减轻，自杀意念严重，两组之间总体改善分数存在较大差异。这个RUPP-PI站点的专业知识和经验也将用于培训新的调查人员。在创建TASA的过程中，一个由8名申请者组成的协作小组锻造了合作的能力。

DESCRIPTION (provided by applicant) : This U10 proposal, RUPP-PI in Pittsburgh is to establish an NIMH Research Unit for Pediatric Psychopharmacology-Psychosocial Intervention in Pittsburgh. The proposed unit builds on the strengths of the Pittsburgh site in clinical epidemiology of mood disorders and suicidal behavior, psychosocial treatment development, pharmacokinetics of SSRI's, and participation in numerous success- fully performed, single and multi-site clinical trials involving CBT, antidepressants, and their combination for mood and anxiety disorders. Resources to support this program of research and training include a T32 postdoctoral training grant in child psychiatry research, an Intervention Research Center on early-onset mood and anxiety disorders, a RUPP devoted to pharmacokinetics of antidepressants, and a state-supported specialty clinic for mood disorders and suicidal behavior. The exemplar research protocol, "Treatment of Adolescent Suicide Attempters" (TASA), targets a major public health issue: although adolescents in this country suffer 2 million suicide attempts annually, no large scale, multimodal controlled intervention studies for this condition have been conducted. The proposed 5-year study will determine the effectiveness of a multi-modal treatment intervention to prevent further reattempts in 480 depressed adolescents attempters, ages 12 to 18, at 8 sites. The Experimental Treatment Group will receive a 24-week course of antidepressant medication management (MM), and cognitive behavioral therapy. The Control Treatment Group will be referred to a community provider for standard clinical care plus enhanced clinical monitoring and case management to encourage treatment adherence. Both groups will be assessed at baseline 2, 4, 8, 12, 24, 36 and 48 weeks by an independent evaluator blind to treatment assignment. We hypothesize that the experimental treatment will result in fewer suicide attempts, diminished depression and severity of suicidal ideation, and greater global improvement scores differ between the 2 groups over a one-year period of observation. The expertise and experience at this RUPP-PI site also will be directed to train new investigators. In creating TASA, a collaborative group of 8 applicants forged the ability to work together.