RUPP-PI

鲁普-PI

• 批准号: 6949733
• 负责人: OSCAR G BUKSTEIN
• 金额: $ 51.98万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-06 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6949733
• 关键词: adolescence (12-20); antidepressants; behavioral /social science research tag; citalopram; clinical depression; clinical research; clinical trials; cognitive behavior therapy; combination therapy; cooperative study; fluoxetine; human subject; human therapy evaluation; longitudinal human study; mental disorder chemotherapy; mental disorder prevention; paroxetine; patient oriented research; pediatrics; psychological tests; psychopharmacology; serotonin inhibitor; suicide

DESCRIPTION (provided by applicant) : This U10 proposal, RUPP-PI in Pittsburgh is to establish an NIMH Research Unit for Pediatric Psychopharmacology-Psychosocial Intervention in Pittsburgh. The proposed unit builds on the strengths of the Pittsburgh site in clinical epidemiology of mood disorders and suicidal behavior, psychosocial treatment development, pharmacokinetics of SSRI's, and participation in numerous success- fully performed, single and multi-site clinical trials involving CBT, antidepressants, and their combination for mood and anxiety disorders. Resources to support this program of research and training include a T32 postdoctoral training grant in child psychiatry research, an Intervention Research Center on early-onset mood and anxiety disorders, a RUPP devoted to pharmacokinetics of antidepressants, and a state-supported specialty clinic for mood disorders and suicidal behavior. The exemplar research protocol, "Treatment of Adolescent Suicide Attempters" (TASA), targets a major public health issue: although adolescents in this country suffer 2 million suicide attempts annually, no large scale, multimodal controlled intervention studies for this condition have been conducted. The proposed 5-year study will determine the effectiveness of a multi-modal treatment intervention to prevent further reattempts in 480 depressed adolescents attempters, ages 12 to 18, at 8 sites. The Experimental Treatment Group will receive a 24-week course of antidepressant medication management (MM), and cognitive behavioral therapy. The Control Treatment Group will be referred to a community provider for standard clinical care plus enhanced clinical monitoring and case management to encourage treatment adherence. Both groups will be assessed at baseline 2, 4, 8, 12, 24, 36 and 48 weeks by an independent evaluator blind to treatment assignment. We hypothesize that the experimental treatment will result in fewer suicide attempts, diminished depression and severity of suicidal ideation, and greater global improvement scores differ between the 2 groups over a one-year period of observation. The expertise and experience at this RUPP-PI site also will be directed to train new investigators. In creating TASA, a collaborative group of 8 applicants forged the ability to work together.

描述（由申请人提供）：这项U10提案，匹兹堡的RUPP-PI将在匹兹堡建立一个儿科精神药理学-心理社会干预的NIMH研究单位。拟议的单位建立在匹兹堡中心在情绪障碍和自杀行为的临床流行病学、心理社会治疗开发、SSRI 的药代动力学以及参与大量成功进行的单点和多点临床试验（涉及 CBT、抗抑郁药及其组合治疗情绪和焦虑症）方面的优势之上。支持该研究和培训计划的资源包括儿童精神病学研究方面的 T32 博士后培训补助金、早发性情绪和焦虑障碍干预研究中心、致力于抗抑郁药药代动力学的 RUPP 以及国家支持的情绪障碍和自杀行为专业诊所。典型的研究方案“青少年自杀未遂者的治疗”(TASA) 针对一个重大公共卫生问题：尽管该国青少年每年有 200 万次自杀未遂，但尚未针对这种情况进行大规模、多模式控制干预研究。拟议的为期 5 年的研究将确定多模式治疗干预的有效性，以防止在 8 个地点的 480 名 12 至 18 岁的抑郁青少年尝试者进一步尝试。实验治疗组将接受为期 24 周的抗抑郁药物管理 (MM) 和认知行为治疗课程。对照治疗组将被转介给社区提供者进行标准临床护理，并加强临床监测和病例管理，以鼓励治疗依从性。两组患者均将在基线第 2、4、8、12、24、36 和 48 周由一位对治疗分配不知情的独立评估员进行评估。我们假设，在一年的观察期内，实验性治疗将导致两组之间的自杀企图减少、抑郁和自杀意念的严重程度减轻，以及更大的总体改善分数差异。该 RUPP-PI 站点的专业知识和经验也将用于培训新的研究人员。在创建 TASA 的过程中，由 8 名申请人组成的协作小组培养了共同工作的能力。