RUPP-PI

描述（由申请人提供）：本U10提案，匹兹堡RUPP-PI是为了在匹兹堡建立一个NIMH儿科精神药理学-心理社会干预研究单位。拟议的单位建立在匹兹堡网站的优势，在临床流行病学的情绪障碍和自杀行为，社会心理治疗的发展，药代动力学的SSRI的，并参与了许多成功-充分执行，单和多站点临床试验，涉及CBT，抗抑郁药，以及他们的组合情绪和焦虑症。支持这项研究和培训计划的资源包括儿童精神病学研究的T32博士后培训补助金，早发性情绪和焦虑症干预研究中心，致力于抗抑郁药药代动力学的RUPP，以及国家支持的情绪障碍和自杀行为专科诊所。示范性研究方案“青少年自杀未遂者的治疗”（TASA）针对一个主要的公共卫生问题：尽管该国青少年每年遭受200万次自杀企图，但尚未进行针对这种情况的大规模多模式对照干预研究。这项为期5年的研究将确定多模式治疗干预的有效性，以防止在8个地点的480名12至18岁的抑郁症青少年再次尝试。实验治疗组将接受为期24周的抗抑郁药物管理（MM）和认知行为治疗。对照治疗组将被转介给社区提供者进行标准临床护理，并加强临床监测和病例管理，以鼓励治疗依从性。两组均将在基线2、4、8、12、24、36和48周由对治疗分配不知情的独立评价者进行评估。我们假设，实验性治疗将导致更少的自杀企图，减少抑郁和自杀意念的严重程度，并在一年的观察期内，两组之间的整体改善评分差异更大。RUPP-PI研究中心的专业知识和经验也将用于培训新的研究者。在创建TASA的过程中，一个由8名申请人组成的协作小组锻造了共同工作的能力。

DESCRIPTION (provided by applicant) : This U10 proposal, RUPP-PI in Pittsburgh is to establish an NIMH Research Unit for Pediatric Psychopharmacology-Psychosocial Intervention in Pittsburgh. The proposed unit builds on the strengths of the Pittsburgh site in clinical epidemiology of mood disorders and suicidal behavior, psychosocial treatment development, pharmacokinetics of SSRI's, and participation in numerous success- fully performed, single and multi-site clinical trials involving CBT, antidepressants, and their combination for mood and anxiety disorders. Resources to support this program of research and training include a T32 postdoctoral training grant in child psychiatry research, an Intervention Research Center on early-onset mood and anxiety disorders, a RUPP devoted to pharmacokinetics of antidepressants, and a state-supported specialty clinic for mood disorders and suicidal behavior. The exemplar research protocol, "Treatment of Adolescent Suicide Attempters" (TASA), targets a major public health issue: although adolescents in this country suffer 2 million suicide attempts annually, no large scale, multimodal controlled intervention studies for this condition have been conducted. The proposed 5-year study will determine the effectiveness of a multi-modal treatment intervention to prevent further reattempts in 480 depressed adolescents attempters, ages 12 to 18, at 8 sites. The Experimental Treatment Group will receive a 24-week course of antidepressant medication management (MM), and cognitive behavioral therapy. The Control Treatment Group will be referred to a community provider for standard clinical care plus enhanced clinical monitoring and case management to encourage treatment adherence. Both groups will be assessed at baseline 2, 4, 8, 12, 24, 36 and 48 weeks by an independent evaluator blind to treatment assignment. We hypothesize that the experimental treatment will result in fewer suicide attempts, diminished depression and severity of suicidal ideation, and greater global improvement scores differ between the 2 groups over a one-year period of observation. The expertise and experience at this RUPP-PI site also will be directed to train new investigators. In creating TASA, a collaborative group of 8 applicants forged the ability to work together.