ZFIN:The Zebrafish Model Organism Database

产品说明：（申请人提供）发现人类基因组中数以万计的基因的功能是理解人类生物学和疾病的必要步骤。包括斑马鱼在内的遗传模式生物在这一发现过程中发挥着关键作用，因为遗传分析可以将基因序列和功能联系起来。模型 生物数据库，如ZFIN，提供了建立这种联系所需的工具。 斑马鱼已经成为一种首要的模式生物，因为强大的技术允许有效地产生和恢复影响发育模式，器官发生，生理和行为的基因的斑马鱼突变。最近的进展使得在转基因斑马鱼和反义寡核苷酸中研究基因功能变得容易。 这些基因中的许多基因的功能在脊椎动物群体中是保守的。因此，对斑马鱼突变的分析提供了对其他脊椎动物（包括人类）基因功能的见解。 ZFIN的长期目标是：a）成为实验室使用斑马鱼的社区数据库资源，B）开发和支持综合斑马鱼遗传、基因组和发育信息，c）维护斑马鱼研究信息的权威参考数据集，d）将该信息广泛链接到其他模式生物和人类数据库中的相应数据，e）促进斑马鱼作为人类生物学模型的使用; f）满足研究界的需要。 该项目将扩大斑马鱼表型的管理，实现ZFIN基因记录的Gene Ontology注释，并将组装的斑马鱼全基因组序列并入ZFIN。 这项工作将为研究人员将基因序列与功能联系起来提供强有力的手段，从而促进基因组组织和进化的跨物种分析以及脊椎动物基因功能和疾病的研究。

DESCRIPTION: (provided by applicant) Discovering the functions of the tens of thousands of genes in the human genome is a required step for understanding human biology and disease. Genetic model organisms, including zebrafish, play a critical role in this discovery process, because genetic analysis can connect gene sequence and function. Model organism databases, like ZFIN, provide tools required to make this connection. Zebrafish has emerged as a premiere model organism because powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene functions in other vertebrates, including humans. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic and developmental information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology and f) to serve the needs of the research community. This project will expand curation of zebrafish phenotypes, implement Gene Ontology annotation of ZFIN gene records and incorporate the assembled zebrafish whole genome sequence into ZFIN. This work will provide a powerful means for researchers to associate gene sequence and function, thus facilitating cross-species analyses of genome organization and evolution as well as studies of vertebrate gene function and disease.