SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY

肯塔基州大学的超级基金基础研究项目是24名教师的共同努力，代表了肯塔基州大学和其他两个机构的17个学术单位。代表肯塔基州大学和其他两个机构的17个学术单位的整体重点。我们计划的总体重点是调查多氯联苯和相关卤代化合物对健康的不良影响的机制;为这些环境污染物开发高度敏感和特异性的传感系统，以开发高度暴露人群的暴露和毒性生物标志物;并探索先进的补救技术和销毁这些卤代化合物的方法。我们的计划有可能提出针对多氯联苯介导的疾病的营养干预措施，如动脉粥样硬化和癌症，这是肯塔基州的关键问题，该州有许多超级基金网站和广泛的地面和地表沃茨污染。提交了七个项目，以支持我们的重点研究，地下和地表沃茨污染。提交的七个项目支持我们的重点研究，包括与健康相关的项目，调查卤代烃在致癌作用中的启动，促进和转移增强剂的机制（项目#1、#3和#7）以及作为内皮细胞和内分泌功能的干扰物（项目#2和#4）涉及用重组系统检测超级基金化学品的环境项目（项目4）、使用重组系统的超级基金化学品销毁和补救技术（项目4）以及销毁和补救技术（项目5）。这些研究项目由四个核心支持：行政（A）;综合（B）;外联（C）;和培训（D）。项目管理将有助于协调、信息传递、实验设计和分析以及研究评估。评估过程的高潮是外部咨询委员会的年度会议，会上对每个项目进行审查并提出建议。合成核心负责合成所有要研究的化合物。外展中心将把研究结果传送给住在超级基金地点附近的阿塞拜疆人。培训核心和研究项目为12名以上的博士生提供培训。总的来说，这个多学科的计划旨在带来广泛的经验和经验，以承担与超级基金化学品，关键的肯塔基州和国家的联邦相关的问题。

The Superfund Basic Research Program at the University of Kentucky is the joint effort of 24 faculty, representing 17 academic units at the University of Kentucky and two other institutions. The overall focus of representing 17 academic units at the University of Kentucky and two other institutions. The overall focus of our Program is to investigate the mechanisms of the adverse health effects of PCBs and related halogenated compounds; to develop highly sensitive and specific sensing systems for these environmental pollutants to develop biomarkers of exposure and toxicity in a highly-exposed human population; and to explore advanced remediation techniques and methods of destruction of these halogenated compounds. Our Program has the potential to propose nutritional interventions against PCB-mediated diseases, such as atherosclerosis and cancer, critical issues in the state of Kentucky, which has numerous Superfund sites and widespread contamination of ground and surface waters. Seven projects, submitted to support our focused research, contamination of ground and surface waters. Seven projects, submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) and as disruptors of endothelial cell and endocrine function (Projects #2 and #4); and environmental projects involving the sensing of Superfund Chemicals with recombinant systems (Project #4), and destruction and remediation technologies of Superfund Chemicals with recombinant systems (Project #4), and destruction and remediation technologies (Project #5). These research projects are supported by four Cores: Administration (A); Synthesis (B); Outreach (C); and Training (D). Project administration will aid in coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of the External Advisory Committee, where each project is reviewed and recommendations made. The synthesis core is responsible for synthesizing all compounds to be studied. The outreach core will transmit research findings to Kentuckians who liver near Superfund sites. The training core and the research projects provide for the training of >12 doctoral students. Overall this multi-disciplinary Program is designed to bring a broad range of experience and experience to bear on problems associated with Superfund chemicals, critical to the Commonwealth of Kentucky and the nation.