Administration Core

项目摘要 肯塔基州大学超级基金研究中心（UK-SRC）将专注于预防和干预 具有促进健康生活方式的总体目标的范例（即，健康营养和增加体力 活动），以减少与接触持久性卤化化学品亚类有关的疾病风险 (e.g. PCBs、TCE和PFAS）。我们的生物医学研究将与环境科学/工程相结合 使用新的传感、补救、归宿和运输科学来预防或减少接触的研究 环境中的风险。我们的生物医学研究是围绕一个完整的生命周期的角度和一个 一种使用动物研究来确定可能的假设的范式，这些假设可以与现有的人类进行测试。 数据库，以进一步确定潜在的干预战略。我们的环境科学研究是综合性的 围绕着一个项目，使用命运和运输科学，以帮助通知技术发展， 新型材料科学，旨在减少有机污染物的暴露，然后可以部署在 现场应用。生物医学和环境科学项目都是围绕一组共同的 污染物和使用动物模型来测试这些污染物的毒性和不同的补救措施， 产品.提供最佳的支持环境和必要的基础设施， 中心的目标，我们提出了四个具体的目标，我们的行政核心（ADMC）：1）活动管理 2）双向沟通战略，3）伙伴关系和技术转让，以及4） 评价和管理程序。管理和整合职能得到促进， 中心会议、ADMC领导层和实习生都是从各个研究项目中挑选出来的。双- 与其他SRP中心和机构科学家进行定向沟通，并将研究成果翻译给其他 利益相关者现在完全集成在ADMC中，并由专门的研究翻译进行监督 协调员，由一名通讯主任提供支助。ADMC有效地促进了由仲裁员发起的 研究翻译和技术转让功能，利用新的集成数据管理和 分析核心沿着多方向内部（例如NIH资助的英国临床和转化中心 科学（CCTS）为什么计划，英国P30试点赠款，肯塔基州水研究所）和外部（如环保署， ADSTR，肯塔基州能源和环境内阁（KYEEC），ARCADIS顾问，个人水 公用事业）伙伴关系。评估和管理过程由ADMC主任在协助下监督 程序管理员。ADMC的重点是建立和维护一个持续的 改进开发过程，沿着内部和外部关系，使英国SRC能够 不仅有助于重要的科学发现，而且有助于合作进程和创新 与国家超级基金研究计划有关的努力。

PROJECT SUMMARY The University of Kentucky Superfund Research Center (UK-SRC) will focus on a prevention and intervention paradigm with an overarching goal to promote healthy lifestyles (i.e., healthful nutrition and increased physical activity) to reduce disease risks associated with exposure to a subclass of persistent halogenated chemicals (e.g. PCBs, TCE, and PFAS). Our biomedical research will be coupled with environmental science/engineering research that uses novel sensing, remediation, and fate and transport science to prevent or reduce exposure risks in the environment. Our biomedical research is integrated around a full life-span perspective and a paradigm that uses animal studies to identify possible hypotheses that can be tested against existing human databases to further identify potential intervention strategies. Our environmental science research is integrated around a project cross-talk that uses fate and transport science to help inform technology development using novel material science designed to reduce exposure to organic pollutants and that can then be deployed in field applications. Both biomedical and environmental science projects are crosslinked around a common set of pollutants and the use of animal models to test the toxicity of these pollutants and different remediation by- products. To provide an optimal support environment and the requisite infrastructure to accomplish the Center’s goal, we propose four specific aims for our Administrative Core (ADMC): 1) activities management and integration, 2) bi-directional communication strategies, 3) partnerships and technology transfer, and 4) evaluation and management processes. Management and integration functions are facilitated by monthly Center meetings, and ADMC leadership and trainee interns are drawn from the individual research projects. Bi- directional communication with other SRP centers and agency scientists and research translation to other stakeholders are now fully integrated within the ADMC and overseen by a dedicated research translation coordinator with support from a communications director. The ADMC effectively facilities investigator-initiated research translation and technology transfer functions by leveraging a new integrated Data Management and Analysis Core along with multidirectional internal (e.g. NIH funded UK Center for Clinical and Translational Science (CCTS) WHY program, UK P30 pilot grants, Kentucky Water Institute) and external (e.g. EPA, ADSTR, Kentucky Cabinet for Energy and the Environment (KYEEC), ARCADIS Consultants, individual water utilities) partnerships. Evaluation and management processes are overseen by the ADMC director as assisted by the program administer. The focus of the ADMC on the establishment and maintenance of a continuous improvement development processes, along with internal and external relationships, positions the UK-SRC to contribute not only important scientific findings but also to the collaborative processes and innovative endeavors associated with the national Superfund Research Program.