SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY

肯塔基大学的超级基金基础研究项目是由24名教师共同努力的，他们代表了肯塔基大学和另外两个机构的17个学术单位。代表肯塔基大学和其他两个机构的17个学术单位的总体重点。本计划的总体重点是调查多氯联苯和相关卤化化合物对健康不利影响的机制；开发针对这些环境污染物的高灵敏度和特异性传感系统，以开发高度暴露人群暴露和毒性的生物标志物；并探索先进的修复技术和破坏这些卤化化合物的方法。我们的项目有潜力提出针对多氯联苯介导的疾病的营养干预措施，如动脉粥样硬化和癌症，这是肯塔基州的关键问题，该州有许多超级基金站点，地下水和地表水受到广泛污染。七个项目，提交来支持我们的重点研究，地下水和地表水的污染。为支持我们的重点研究而提交的七个项目包括与健康相关的项目，研究卤化碳氢化合物在致癌过程中具有启动、促进和转移增强作用的机制（项目#1、#3和#7），以及作为内皮细胞和内分泌功能的干扰物（项目#2和#4）；以及涉及利用重组系统感知超级基金化学品（项目#4）、利用重组系统对超级基金化学品进行破坏和修复技术（项目#4）以及破坏和修复技术（项目#5）的环境项目。这些研究项目得到四个核心的支持：行政管理(A)；合成(B);外展(C);和培训(D)项目管理将有助于协调、信息传递、实验设计和分析以及研究评估。评估过程在外部咨询委员会的年度会议上达到高潮，在会议上审查每个项目并提出建议。合成核心负责合成所有要研究的化合物。外展核心将把研究结果传递给住在超级基金所在地附近的肯塔基人。培养核心和研究项目为培养博士研究生提供了bb1012名。总的来说，这个多学科项目旨在为与超级基金化学品相关的问题带来广泛的经验和经验，这对肯塔基州和国家至关重要。

The Superfund Basic Research Program at the University of Kentucky is the joint effort of 24 faculty, representing 17 academic units at the University of Kentucky and two other institutions. The overall focus of representing 17 academic units at the University of Kentucky and two other institutions. The overall focus of our Program is to investigate the mechanisms of the adverse health effects of PCBs and related halogenated compounds; to develop highly sensitive and specific sensing systems for these environmental pollutants to develop biomarkers of exposure and toxicity in a highly-exposed human population; and to explore advanced remediation techniques and methods of destruction of these halogenated compounds. Our Program has the potential to propose nutritional interventions against PCB-mediated diseases, such as atherosclerosis and cancer, critical issues in the state of Kentucky, which has numerous Superfund sites and widespread contamination of ground and surface waters. Seven projects, submitted to support our focused research, contamination of ground and surface waters. Seven projects, submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) and as disruptors of endothelial cell and endocrine function (Projects #2 and #4); and environmental projects involving the sensing of Superfund Chemicals with recombinant systems (Project #4), and destruction and remediation technologies of Superfund Chemicals with recombinant systems (Project #4), and destruction and remediation technologies (Project #5). These research projects are supported by four Cores: Administration (A); Synthesis (B); Outreach (C); and Training (D). Project administration will aid in coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of the External Advisory Committee, where each project is reviewed and recommendations made. The synthesis core is responsible for synthesizing all compounds to be studied. The outreach core will transmit research findings to Kentuckians who liver near Superfund sites. The training core and the research projects provide for the training of >12 doctoral students. Overall this multi-disciplinary Program is designed to bring a broad range of experience and experience to bear on problems associated with Superfund chemicals, critical to the Commonwealth of Kentucky and the nation.