MOLECULAR PATHOGENESIS OF CHLAMYDIA-INDUCED ATHEROGENESI
MOLECULAR PATHOGENESIS OF CHLAMYDIA-INDUCED ATHEROGENESI
批准号:
6729065
负责人:
Moshe Arditi
金额:
$38.25万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-01 至 2007-03-31
关键词:
Chlamydiaceaeatherosclerosisbiological signal transductioncell adhesion moleculescell migrationdisease /disorder etiologygene targetingheat shock proteinslaboratory mouseleukocyte activation /transformationlipopolysaccharidesmacrophagemembrane proteinsmitogen activated protein kinasemolecular pathologynuclear factor kappa betareceptorvascular endothelium
中文摘要
描述(改编自申请人摘要):目标是定义
英文摘要
DESCRIPTION (Adapted from the Applicant's Abstract): The goal is to define
mechanisms leading to the development and progression of chlamydiae-mediated
atherosclerosis. Approaches will center on studying signaling mechanisms for
cLPS and cHsp60, effector molecules known to activate host pro-inflammatory
pathways. The hypothesis to be investigated is that cLPS and cHsp60 utilize the
Toll-like Receptor-4 (TLR-4) to activate macrophages and endothelial cells via
NF-kB and MAPK through myeloid differentiation protein (MyD88). The effects of
this activation will lead to increased expression of pro-inflammatory cytokines
(IL-6, IL-8), adhesion molecules (ICAM-1 VCAM-1), growth factors (M-CSF),
cyclooxygenase-2 (Cox-2) and enhanced transendothelial cell migration of
monocytes; all factors implicated in atherogenesis. The hypothesis also will be
tested in vivo by determining if apo-E-/-, TLR-4-/- double knockout mice remain
indifferent to C. pneumoniae-induced accelerated lesion progression. The
specific aims are to (1) determine if TLR-4 is the signaling receptor for cLPS
and cHsp60 and to investigate the signaling pathways induced (ERK1/ERK2,
p38MAPK and JNK) and other down-stream events leading to NK-kB activation; (2)
to define the molecular mechanisms involved in cLPS and cHsp60-induced
transendothelial cell migration of monocytes; and (3) to create double knockout
mutants in mice (TLR4-/-, apoE-/- and MtD88-/-, apoE -/-) to investigate the
contributions of TLR-4 and MyD88 in the initiation and progression of
atherosclerosis in the presence and absence of C. pneumoniae infection. The
results of these studies are expected to lead to new targets for intervention
and prevention of coronary atherosclerosis.
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会议论文
RNA-Mediated Inter-Organelle Communication in Atherosclerosis
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批准号:10170419
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项目类别:
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资助金额:$49.89万
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财政年份:2020
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依托单位:
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
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批准号:10683145
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项目类别:
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资助金额:$58.24万
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财政年份:2020
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负责人:Moshe Arditi
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依托单位:
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
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批准号:10668782
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项目类别:
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资助金额:$9.91万
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财政年份:2020
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负责人:Moshe Arditi
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依托单位:
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
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批准号:10269029
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项目类别:
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资助金额:$58.24万
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财政年份:2020
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负责人:Moshe Arditi
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依托单位:
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
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批准号:10462644
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项目类别:
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资助金额:$58.24万
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财政年份:2020
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负责人:Moshe Arditi
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Biological role of SARS-CoV2 Superantigenic structure in hyperinflammatory syndromes
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批准号:10205906
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项目类别:
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资助金额:$18.49万
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财政年份:2020
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负责人:Moshe Arditi
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依托单位:
Role of neutrophils and eosinophils in bacterial ligand-induced vasculitis
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批准号:10710315
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项目类别:
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资助金额:$19.17万
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财政年份:2020
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负责人:Moshe Arditi
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依托单位:
RNA-Mediated Inter-Organelle Communication in Atherosclerosis
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批准号:10630220
-
项目类别:
-
资助金额:$49.89万
-
财政年份:2020
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负责人:Moshe Arditi
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依托单位:
RNA-Mediated Inter-Organelle Communication in Atherosclerosis
-
批准号:10428386
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项目类别:
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资助金额:$49.89万
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财政年份:2020
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负责人:Moshe Arditi
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依托单位:
Atherosclerosis in SLE - OGG-1 as a novel target for therapeutic intervention
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批准号:9306766
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项目类别:
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资助金额:$26.25万
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财政年份:2016
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负责人:Moshe Arditi
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依托单位:
Interaction with Rip2 and Th17 in Chronic Inflammation
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批准号:9217562
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项目类别:
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资助金额:$43.75万
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财政年份:2016
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负责人:Moshe Arditi
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依托单位:
Atherosclerosis in SLE - OGG-1 as a novel target for therapeutic intervention
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批准号:9179934
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项目类别:
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资助金额:$21.88万
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财政年份:2016
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负责人:Moshe Arditi
-
依托单位:
Host Immune Responses to Chlamydia Pneumonaie Infection
-
批准号:8904888
-
项目类别:
-
资助金额:$42.5万
-
财政年份:2014
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负责人:Moshe Arditi
-
依托单位:
Mitochondrial DNA Damage and Inflammasome Activation in Vascular Inflammation
-
批准号:8776918
-
项目类别:
-
资助金额:$25.05万
-
财政年份:2013
-
负责人:Moshe Arditi
-
依托单位:
Mitochondrial DNA Damage and Inflammasome Activation in Vascular Inflammation
-
批准号:8641826
-
项目类别:
-
资助金额:$20.88万
-
财政年份:2013
-
负责人:Moshe Arditi
-
依托单位:
Potential Role of IL-1B Therapies for Treatment of Vasculitis of Kawasaki Disease
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批准号:8226576
-
项目类别:
-
资助金额:$8.35万
-
财政年份:2012
-
负责人:Moshe Arditi
-
依托单位:
Potential Role of IL-1B Therapies for Treatment of Vasculitis of Kawasaki Disease
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批准号:8415498
-
项目类别:
-
资助金额:$8.35万
-
财政年份:2012
-
负责人:Moshe Arditi
-
依托单位:
The Cedars-Sinai Immunobiology Training Program
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批准号:8136194
-
项目类别:
-
资助金额:$19.25万
-
财政年份:2010
-
负责人:Moshe Arditi
-
依托单位:
The Cedars-Sinai Immunobiology Training Program
-
批准号:8494529
-
项目类别:
-
资助金额:$18.5万
-
财政年份:2010
-
负责人:Moshe Arditi
-
依托单位:
The Cedars-Sinai Immunobiology Training Program
-
批准号:7942363
-
项目类别:
-
资助金额:$18.95万
-
财政年份:2010
-
负责人:Moshe Arditi
-
依托单位:
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