Inflammation and Cardiovascular Disease in RA

RA 中的炎症和心血管疾病

• 批准号: 6778598
• 负责人: Joan Marie Bathon
• 金额: $ 54.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6778598
• 关键词: atherosclerosis; bioimaging /biomedical imaging; biomarker; calcium; cardiovascular disorder; cardiovascular disorder risk; cardiovascular imaging /visualization; clinical research; comorbidity; computed axial tomography; data collection methodology /evaluation; heart function; heart sonography; heart ventricle; human middle age (35-64); human old age (65+); human subject; inflammation; longitudinal human study; magnetic resonance imaging; medical complication; outcomes research; pathologic process; patient oriented research; rheumatoid arthritis

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is a major cause of morbidity and mortality in rheumatoid arthritis (RA). CV-related deaths, congestive heart failure, and acute CV events are increased 2-4 fold in RA patients compared to matched controls, but the prevalence of conventional risk factors for CVD is not increased. We hypothesize that inflammation due to RA promotes and exacerbates CVD, independent of conventional CV risk factors. This application is an ancillary proposal to the Multi-Ethnic Study of Atherosclerosis (MESA). We will compare the prevalence and progression of subclinical CVD in 200 RA patients to 1066 non-RA MESA participants from the Hopkins MESA Field Center. The degree to which inflammation contributes to increased CVD in RA patients will be examined, after adjusting for conventional CV risk factors. Our specific aims are as follows: Specific Aim 1. In a cross-sectional analysis we will compare a measure of atherosclerosis (coronary calcium) and measures of left ventricular (LV) dysfunction (by magnetic resonance imaging) between RA patients and controls. We will determine whether differences between the groups in coronary calcium and LV dysfunction are explained by serum markers of inflammation in RA (e.g., CRP, interleukin-6, soluble adhesion molecules). Specific Aim 2. In a prospective analysis, we will compare the changes in coronary calcium between RA patients and controls. We will determine the degree to which elevated serum markers of inflammation contribute to differences in progression of coronary calcium. Specific Aim 3. We will assess the associations of various markers of inflammation and disease activity/severity, as well as conventional CV risk factors, with coronary calcium and LV dysfunction at baseline and over three years, among RA patients. Particularly, the potential dose-response relationships of various markers of inflammation and disease activity/severity to coronary calcium and LV dysfunction will be examined.

描述（由申请人提供）：心血管疾病（CVD）是类风湿关节炎（RA）发病率和死亡率的主要原因。 与匹配的对照组相比，RA患者与CV相关的死亡，充血性心力衰竭和急性CV事件增加了2-4倍，但CVD常规风险因素的流行率并没有增加。 我们假设由于RA引起的炎症会促进和加剧CVD，而与常规简历风险因素无关。该应用是对动脉粥样硬化多种族研究（MESA）的辅助建议。我们将比较200名RA患者的亚临床CVD的患病率和进展与霍普金斯梅萨场中心的1066名非RA MESA参与者。调整常规简历危险因素后，将检查炎症导致RA患者CVD增加的程度。我们的具体目的如下： 在横截面分析中，我们将比较RA患者和对照组之间的动脉粥样硬化（冠状动脉钙）和左心室（LV）功能障碍（通过磁共振成像）的度量。我们将确定冠状动脉钙和LV功能障碍中两组之间的差异是否通过RA中炎症的血清标记（例如CRP，白介素6，可溶性粘附分子）来解释。 具体目标2。在前瞻性分析中，我们将比较RA患者与对照组之间的冠状动脉钙的变化。我们将确定炎症的血清标记升高导致冠状动脉钙进展差异的程度。 具体目的3。我们将评估炎症和疾病活动/严重程度的各种标记的关联，以及常规的简历危险因素，与RA患者相比，基线和三年以上的冠状动脉钙和LV功能障碍。特别是，将检查各种炎症和疾病活性/严重程度与冠状动脉钙和LV功能障碍的潜在剂量反应关系。