Gender Differences in Leptin Signaling
瘦素信号传导的性别差异
基本信息
- 批准号:6666845
- 负责人:
- 金额:$ 3.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-12-01 至 2004-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (provided by applicant): Obesity is a health problem of enormous proportions with few effective therapeutic treatments. The regulation of body
weight and body adiposity occurs through coordinated actions of peripheral and
central mechanisms, which control food intake and energy expenditure. Leptin is
secreted from adipocytes and functions as a peripheral signal of lipid stores
to the brain. There are gender difference in percent body fat as well as in the
distribution of body fat, and we have determined there are gender differences
in sensitivity to centrally administered leptin. The present experiments are
proposed to determine if gonadal hormones, specifically estrogen, effects the
expression and sensitivity of the critical signaling variant of the leptin
receptor (Ob-Rb). The first series of experiments will investigate if there are
gender differences in distribution and expression of the Ob-Rb using in situ
hybridization real-time PCR and Western blot analysis. In the second set of
experiments, we will investigate if there are differences in the activation of
intracellular proteins activated as part of the leptin receptor-signaling
cascade, STAT3 and SOCS-3, by utilizing Western Blot analysis and Ribonuclease
Protection Assays. Lastly, we will assess whether the gonadal hormone estrogen,
affects Ob-Rb expression and activation, by comparing gonadectomized animals
with and without hormone replacement and measuring Ob-Rb distribution,
expression, and activation.
描述:(由申请人提供):肥胖是一个巨大的健康问题,很少有有效的治疗方法。身体的调节
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Deborah J Clegg其他文献
Estrogen and Leptin Regulation of Endocrinological Features of Anorexia Nervosa
雌激素和瘦素对神经性厌食症内分泌特征的调节
- DOI:
10.1038/npp.2012.176 - 发表时间:
2012-11-13 - 期刊:
- 影响因子:7.100
- 作者:
Lynda M Brown;Deborah J Clegg - 通讯作者:
Deborah J Clegg
Deborah J Clegg的其他文献
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{{ truncateString('Deborah J Clegg', 18)}}的其他基金
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7647234 - 财政年份:2006
- 资助金额:
$ 3.08万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7148400 - 财政年份:2006
- 资助金额:
$ 3.08万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7261314 - 财政年份:2006
- 资助金额:
$ 3.08万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7463920 - 财政年份:2006
- 资助金额:
$ 3.08万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7776623 - 财政年份:2006
- 资助金额:
$ 3.08万 - 项目类别:
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