CORE--Animal
核心--动物
基本信息
- 批准号:7089245
- 负责人:
- 金额:$ 26.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The program project is aimed at understanding how diets high in fat lead to increased levels of
defended body weight. Our overall strategy is to explore a model of dietary obesity at many levels and
from multiple perspectives. The Animal & Physiology Core consolidates and centralizes the production of
obese rats and their various control groups for each of the specific projects. Specifically, this core
generates EVERY animal that is used in each of the specific projects and thereby assures that each
experiment enjoys animals that have been treated in an identical manner, thus allowing comparisons
across time, cohorts and projects. There are four primary goals of this core. 1) To generate requisite
animals for the individual projects in any of the various dietary groups described in detail in the
introductory section to the proposal. These groups include rats on a low-fat, semi-purified butter oil-based
diet (LF), rats on a matched high-fat, semi-purified diet (HF), rats receiving the HF diet but with calories
matched (pair-fed) to intake of the LF rats (PHF), rats receiving the LF diet and food-restricted by the
same amount as the PHF: pair fed rats (PLF), and rats with pelleted chow (CHOW). The Core also
generates control rats on HF and LF diets based on olive oil as opposed to butter oil. 2) To develop
novel or modified rat surgical techniques as required by each of the individual projects. 3) To carry out
experiments on behavioral aspects associated with the palatability and meal pattern analysis as well
energy expenditure measurements to determine how the different fatty acids influence consumption and
behaviors associated with body weight regulation. 4) To carry out carcass analysis for body lipid content
on subjects from each of the individual projects. This includes non-invasive (i.e., NMR readings) and
terminal assessments for the entire carcass or specific anatomical subareas (e.g., subcutaneous fat).
Lastly, The Animal & Physiology Core will carry out certain pilot or other experiments necessary for
creating data that are relevant and critical to the other projects. The Animal/Physiology Core personnel
are already facile with all of the techniques required to date that are used to characterize the model;
consequently the personnel are already well-trained and the protocols are all in place to efficiently
accomplish the goals of this essential core.
该项目旨在了解高脂肪饮食是如何导致脂肪含量增加的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Deborah J Clegg其他文献
Estrogen and Leptin Regulation of Endocrinological Features of Anorexia Nervosa
雌激素和瘦素对神经性厌食症内分泌特征的调节
- DOI:
10.1038/npp.2012.176 - 发表时间:
2012-11-13 - 期刊:
- 影响因子:7.100
- 作者:
Lynda M Brown;Deborah J Clegg - 通讯作者:
Deborah J Clegg
Deborah J Clegg的其他文献
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{{ truncateString('Deborah J Clegg', 18)}}的其他基金
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7647234 - 财政年份:2006
- 资助金额:
$ 26.15万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7148400 - 财政年份:2006
- 资助金额:
$ 26.15万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7261314 - 财政年份:2006
- 资助金额:
$ 26.15万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7463920 - 财政年份:2006
- 资助金额:
$ 26.15万 - 项目类别:
Regulation of Food Intake and Body Weight by Hypothalamic ERAlpha
下丘脑 ERAlpha 对食物摄入量和体重的调节
- 批准号:
7776623 - 财政年份:2006
- 资助金额:
$ 26.15万 - 项目类别:
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