Total synthesis of Zoanthamine

描述（由申请人提供）：我们的目标是开发一种可行的合成方法，以简洁的方式生产泽安那敏和该生物碱家族的其他成员，如去甲泽安那敏。这些生物碱大多具有高度功能化的反式癸酮和杂环胺环体系，并至少具有三个季手性中心（杂蒽醌为C-9， C-12, C-22）。在一个模型系统中，发现Zoanthamine及其近缘物具有抑制肉豆酸酯佛波引起的炎症的作用。诺佐那敏抑制P388小鼠白血病细胞的生长。此外，去甲氰胺抑制IL-6的产生。最近，有报道称，黄花胺类生物碱抑制骨量的下降。zooanthamine核心的构建将引导我们有希望建立一个类似物库，以进一步研究它们作为骨质疏松药物和/或抗炎药物的候选药物的潜力。

DESCRIPTION (provided by applicant): Our goal is to develop a feasible synthetic procedure that can yield Zoanthamine and other members of this alkaloid family such as norzoanthamine in a concise manner. Most of these alkaloids possess highly functionalized trans-decalone and heterocyclic aminal ring system along with at least three quaternary chiral centers (C-9, C-12, C-22 for zoanthamine). Zoanthamine and its relatives were found to inhibit phorbol myristate acetate induced inflammation in a model system. Norzoanthamine was found to inhibit the growth of P388 murine leukemia cell cultures. In addition, norzoanthamine inhibits IL-6 production. Recently, it has been reported that zoanthamine-type alkaloids suppress the decrease in bone weight. The construction of the core of zoanthamine will lead us to hopefully develop a library of its analogs to further study their potential as candidates for an osteoporotic drug and/or an anti-inflammatory drug.